Trial reportDer Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete2011
[A new topically applied morphine gel for the pain treatment in patients with chronic leg ulcers: first results of a clinical investigation].
Trial report in Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 35 citations in OpenAlex.
- Hydrogel-Based Formulations to Deliver Analgesic Drugs: A Scoping Review of Applications and Efficacy.Biomedicines · 2025Review
- [Pyoderma gangrenosum: pathogenesis, diagnosis, and treatment].Dermatologie (Heidelberg, Germany) · 2025Review
- [Wounds caused by vasculitis-Current classification, diagnostics and treatment].Zeitschrift fur Gerontologie und Geriatrie · 2023Review
- [Treating wounds with extemporaneous preparations].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2019Article
- Ulcerated necrobiosis lipoidica as a rare cause for chronic leg ulcers: case report series of ten patients.International wound journal · 2015Article
- Recent developments in topical wound therapy: impact of antimicrobiological changes and rebalancing the wound milieu.BioMed research international · 2014Review
- [Hand-foot syndrome with tyrosine kinase inhibitor therapy: treatment recommendations].Der Urologe. Ausg. A · 2013Article
- [Multilocular pyoderma gangrenosum after uterus resection].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe approach to patients with chronic leg ulcers should include not only an accurate diagnosis with appropriate therapy fort he underlying disease, but also the development of effective analgesia. To assess the analgesic effect of topical morphine, we developed a new morphine gel with polihexanide as a preservative for the local pain treatment. PATIENTS AND
methodsWe have studied 30 patients with painful chronic leg ulcers with an average age of 66 years. The respective pain intensity was assessed 24 hours after application of the morphine hydrogel and objectified with a visual analogue scale (VAS) ranged from 0 to 10.
resultsAll investigated patients had a pain intensity of at least 4 points before the topical application of the morphine gel; the average pain intensity was 7.8. After application of the morphine gel, a significant reduction of the average pain intensity was observed, with an average pain intensity of 4.5.
conclusionThese first clinical results with the new morphine gel suggest that at least fort he first 24 hours it combines the advantages of a moist wound healing and a local pain treatment. This new development is certainly a promising therapeutic alternative for pain treatment in patients with chronic leg ulcers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.