ReviewPediatric nephrology (Berlin, Germany)2012
Hyperammonemia in review: pathophysiology, diagnosis, and treatment.
Review in Pediatric nephrology (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 1 synthesis or guideline pooled it, 201 citations in OpenAlex.
- Valproate-induced hyperammonemic encephalopathy in neurosurgical patients: Our experience and systematic literature review.Neurosurgical review · 2024Pooled it
- Plasma ammonia concentrations in extremely low birthweight infants in the first week after birth: secondary analysis from the ProVIDe randomized clinical trial.Pediatric research · 2020Trial
- Amino Acid Deficiency Secondary to Continuous Venovenous Hemofiltration in Acute Decompensation of Organic Acidemias: An Anabolic Dead End?Critical care explorations · 2026Observational
- Deleterious in vitro effects of ammonia and accumulated urea cycle amino acids on leukocyte DNA: assessment of the antioxidant effects of N-acetylcysteine and L-carnitine.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Article
- "Why won't the ammonia go down?": ammonia management while on continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026Article
- Liver transplantation for propionic acidemia: Survival and metabolic outcomes.Hepatology communications · 2026Article
- Hyperammonemic encephalopathy after 5-fluorouracil chemotherapy.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- Non-genitourinary Ureaplasma urealyticum infections in solid organ transplant recipients: a case report and literature review.BMC infectious diseases · 2025Review
- Ammonia metabolism and ammonia-induced cell death: role in cancer therapy.Cell communication and signaling : CCS · 2025Review
- Hypercapnia-Induced Noncirrhotic Hyperammonemia (HIH): Unveiling an Unrecognized Association.Cureus · 2025Article
- Valproate-induced hyperammonemic encephalopathy: the role of clinical pharmacists in medication safety-a case report.Journal of medical case reports · 2025Article
- Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma.Science advances · 2025Article
- Janus Kinase Inhibitor: A Possible Cause of Hyperammonemic Encephalopathy?Journal of clinical neurology (Seoul, Korea) · 2025Article
- Nutritional attributes of traditional and commercial apple cultivars growing in West Himalaya, India.Journal of food science and technology · 2025Article
- Mitigating ammonium toxicity in strawberry cultivation: effective fertilization practices for sustainable crop production.BMC plant biology · 2025Article
- Article
- Clinical and biochemical factors associated with hyperammonemia in inpatients with mental disorders treated with valproic acid: a cross-sectional analysis.Therapeutic advances in psychopharmacology · 2025Article
- Safety evaluation of irinotecan: a real-world disproportionality analysis using FAERS and JADER databases during the time period 2004-2024.Frontiers in pharmacology · 2025Article
- Role of carglumic acid in the long-term management of propionic and methylmalonic acidurias.Orphanet journal of rare diseases · 2024Review
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ammonia is an important source of nitrogen and is required for amino acid synthesis. It is also necessary for normal acid-base balance. When present in high concentrations, ammonia is toxic. Endogenous ammonia intoxication can occur when there is impaired capacity of the body to excrete nitrogenous waste, as seen with congenital enzymatic deficiencies. A variety of environmental causes and medications may also lead to ammonia toxicity. Hyperammonemia refers to a clinical condition associated with elevated ammonia levels manifested by a variety of symptoms and signs, including significant central nervous system (CNS) abnormalities. Appropriate and timely management requires a solid understanding of the fundamental pathophysiology, differential diagnosis, and treatment approaches available. The following review discusses the etiology, pathogenesis, differential diagnosis, and treatment of hyperammonemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.