ArticleEnvironmental science and pollution research international2011
Some heterocyclic aromatic compounds are Ah receptor agonists in the DR-CALUX assay and the EROD assay with RTL-W1 cells.
Article in Environmental science and pollution research international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 57 citations in OpenAlex.
- Sulfur-Containing Heterocyclic Aromatic Hydrocarbons Alter Estrogen Metabolism and Cause DNA Damage and Apoptosis in Granulosa Cells.International journal of molecular sciences · 2025Article
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- Extensive chemical and bioassay analysis of polycyclic aromatic compounds in a creosote-contaminated superfund soil following steam enhanced extraction.Environmental pollution (Barking, Essex : 1987) · 2022Article
- A novel contact assay for testing aryl hydrocarbon receptor (AhR)-mediated toxicity of chemicals and whole sediments in zebrafish (Danio rerio) embryos.Environmental science and pollution research international · 2015Article
- Time-dependent expression and activity of cytochrome P450 1s in early life-stages of the zebrafish (Danio rerio).Environmental science and pollution research international · 2015Article
- Intact cell mass spectrometry as a rapid and specific tool for the differentiation of toxic effects in cell-based ecotoxicological test systems.Analytical and bioanalytical chemistry · 2015Article
- Combined use of PAH levels and EROD activities in the determination of PAH pollution in flathead mullet (Mugil cephalus) caught from the West Black Sea coast of Turkey.Environmental science and pollution research international · 2015Article
- Article
- Genotoxicity of heterocyclic PAHs in the micronucleus assay with the fish liver cell line RTL-W1.PloS one · 2014Article
- Chemical and bioanalytical characterisation of PAHs in risk assessment of remediated PAH-contaminated soils.Environmental science and pollution research international · 2013Article
- Contribution of priority PAHs and POPs to Ah receptor-mediated activities in sediment samples from the River Elbe Estuary, Germany.PloS one · 2013Article
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10 authors at 5 institutions in 3 countries.
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Abstract
purposeHeterocyclic aromatic compounds containing nitrogen, sulfur, or oxygen heteroatoms (NSO-HET) have been detected in air, soil, marine, and freshwater systems. However, only few publications are available investigating NSO-HET using in vitro bioassays. To support better characterization of environmental samples, selected NSO-HET were screened for dioxin-like activity in two bioassays.
methodsThe present study focuses on the identification and quantification of dioxin-like effects of 12 NSO-HET using the DR-CALUX assay, and the 7-ethoxyresorufin-O-deethylase (EROD) assay with the permanent fish liver cell line RTL-W1. Changes of the total medium compound concentrations during the test procedure due to, e.g., sorption or volatilization were quantified using GC/MS.
resultsThe NSO-HET benzofuran, 2,3-dimethylbenzofuran, dibenzofuran, dibenzothiophen, acridine, xanthene, and carbazole caused a response in the DR-CALUX assay. Only benzofuran and 2,3-dimethylbenzofuran were also positive in the EROD assay. All other compounds were inactive in the EROD assay. Relative potency (REP) values ranged from (2.80 ± 1.32) · 10(-8) to (3.26 ± 2.03) · 10(-6) in the DR-CALUX and from (3.26 ± 0.91) · 10(-7) to (4.87 ± 1.97) · 10(-7) in the EROD assay.
conclusionsThe REP values were comparable to those of larger polycyclic aromatic hydrocarbons, e.g., fluoranthene and pyrene. Thus, and because of the ubiquitous distribution of heterocyclic aromatic compounds in the environment, the provided data will further facilitate the bioanalytical and analytical characterization of environmental samples towards these toxicants.
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