ReviewMolecular medicine (Cambridge, Mass.)2011
Regulation of male fertility by the opioid system.
Review in Molecular medicine (Cambridge, Mass.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 68 citations in OpenAlex.
- Expression of miR-339-3p and OPRM1 in relation to sperm function in male infertility.Andrology · 2026Article
- Building epigenetic risk scores of opioid use disorder: Insights from human postmortem brain data.Translational psychiatry · 2026Article
- Chronic Morphine Treatment Leads to a Global DNA Hypomethylation via Active and Passive Demethylation Mechanisms in mESCs.International journal of molecular sciences · 2025Article
- Intraindividual variability of semen quality, proteome, and sncRNA profiles in a healthy cohort of young adults.Andrology · 2025Article
- A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System.Biomedicines · 2025Review
- The Association between the Gut Microbiota and Erectile Dysfunction.The world journal of men's health · 2024Article
- Influence of substance use on male reproductive health and offspring outcomes.Nature reviews. Urology · 2024Review
- The Cation/Calcium Channel of Sperm (CatSper): A Common Role Played Despite Inter-Species Variation?International journal of molecular sciences · 2023Review
- Men who inject opioids exhibit altered tRNA-Gly-GCC isoforms in semen.Molecular human reproduction · 2023Article
- Opioid replacement therapy with methadone or buprenorphine effects on male mice reproduction.Psychopharmacology · 2023Article
- The effects of morphine abuse on sperm parameters, chromatin integrity and apoptosis in men.JBRA assisted reproduction · 2022Article
- Article
- Consequences of Parental Opioid Exposure on Neurophysiology, Behavior, and Health in the Next Generations.Cold Spring Harbor perspectives in medicine · 2021Review
- (Pro)renin Receptor Is Present in Human Sperm and It Adversely Affects Sperm Fertility Ability.International journal of molecular sciences · 2021Article
- Male infertility due to testicular disorders.The Journal of clinical endocrinology and metabolism · 2021Review
- Evaluation of Enkephalin-Degrading Enzymes in Sperm from Heroin-Addicted Men.International journal of fertility & sterility · 2020Article
- Article
- Reactive oxygen species and male reproductive hormones.Reproductive biology and endocrinology : RB&E · 2018Review
- Expression and Localization of Opioid Receptors in Male Germ Cells and the Implication for Mouse Spermatogenesis.PloS one · 2016Article
- Intravenous iron replacement therapy in eugonadal males with iron-deficiency anemia: Effects on pituitary gonadal axis and sperm parameters; A pilot study.Indian journal of endocrinology and metabolism · 2014Article
Corrections and comments
- Commented on by
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endogenous opioid peptides are substances involved in cell communication. They are present in various organs and tissues of the male and female reproductive tract, suggesting that they may regulate some of the processes involved in reproductive function. In fact, the opioid system that operates as a multi-messenger system can participate in the regulation of reproductive physiology at multiple levels, for example, at the levels of the central nervous system, at the testes level and at sperm level. A better understanding of the implication of the opioid system in reproductive processes may contribute to clarifying the etiology of many cases of infertility and the effect of opiate abuse on fertility. Indeed, a novel biochemical tool for the diagnosis and treatment of male infertility could be based upon components of the opioid system. The presence of the opioid system in sperm cells also represents a novel opportunity for reproductive management, for either enhancing the probability of fertilization or reducing it through the development of novel targeted contraceptives.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.