ArticleLab on a chip2011
Nanochannel confinement: DNA stretch approaching full contour length.
Article in Lab on a chip, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- A Lab-on-a-Chip for the Extraction and Analysis of Single Molecules of DNA from Biological Media.Nanomaterials (Basel, Switzerland) · 2026Article
- The Emergence of Nanofluidics for Single-Biomolecule Manipulation and Sensing.Analytical chemistry · 2025Review
- Optical Genome Mapping: A Machine-Based Platform in Cytogenomics.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Article
- Knot formation of dsDNA pushed inside a nanochannel.Scientific reports · 2022Article
- Limitations of the equivalent neutral polymer assumption for theories describing nanochannel-confined DNA.Physical review. E · 2020Article
- Extension distribution for DNA confined in a nanochannel near the Odijk regime.The Journal of chemical physics · 2019Article
- Simulations corroborate telegraph model predictions for the extension distributions of nanochannel confined DNA.Biomicrofluidics · 2019Article
- Development of 3D printed mesofluidic devices to elute and concentrate DNA.Electrophoresis · 2019Article
- Nanoplumbing with 2D Metamaterials.Small (Weinheim an der Bergstrasse, Germany) · 2019Article
- Article
- A Solid-State Hard Microfluidic-Nanopore Biosensor with Multilayer Fluidics and On-Chip Bioassay/Purification Chamber.Advanced functional materials · 2018Article
- Modelling BioNano optical data and simulation study of genome map assembly.Bioinformatics (Oxford, England) · 2018Article
- TAMRA-polypyrrole for A/T sequence visualization on DNA molecules.Nucleic acids research · 2018Article
- Measuring the wall depletion length of nanoconfined DNA.The Journal of chemical physics · 2018Article
- Non-lithographic nanofluidic channels with precisely controlled circular cross sections.RSC advances · 2018Article
- Distribution of label spacings for genome mapping in nanochannels.Biomicrofluidics · 2018Article
- Evaluation of Blob Theory for the Diffusion of DNA in Nanochannels.Macromolecules · 2018Article
- Determining if DNA Stained with a Cyanine Dye Can Be Digested with Restriction Enzymes.Journal of visualized experiments : JoVE · 2018Article
- One-Parameter Scaling Theory for DNA Extension in a Nanochannel.Physical review letters · 2017Article
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Authors and funding
8 authors.
Funding
Abstract
Fully stretched DNA molecules are becoming a fundamental component of new systems for comprehensive genome analysis. Among a number of approaches for elongating DNA molecules, nanofluidic molecular confinement has received enormous attentions from physical and biological communities for the last several years. Here we demonstrate a well-optimized condition that a DNA molecule can stretch almost to its full contour length: the average stretch is 19.1 µm ± 1.1 µm for YOYO-1 stained λ DNA (21.8 µm contour length) in 250 nm × 400 nm channel, which is the longest stretch value ever reported in any nanochannels or nanoslits. In addition, based on Odijk's polymer physics theory, we interpret our experimental findings as a function of channel dimensions and ionic strengths. Furthermore, we develop a Monte Carlo simulation approach using a primitive model for the rigorous understanding of DNA confinement effects. Collectively, we present a more complete understanding of nanochannel confined DNA stretching via the comparisons to computer simulation results and Odijk's polymer physics theory.
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