Evidence map›Paper›PMID 21430694›Full record

ArticleNature chemistry2011

The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis.

Mohammad R Seyedsayamdost, Rebecca J Case, Roberto Kolter, Jon Clardy

Abstract read
In one paragraph

Article in Nature chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 224 papers.

0numbers the graph read from it
0cells of the map it votes in
224citing papers in PubMed
19.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

224 citing papers in PubMed, 482 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. mBio · 2026
    Article
  6. Review
  7. Algicidal Characteristics ofMicroorganisms · 2026
    Article
  8. Marine BacteriumJournal of natural products · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Exploring the interactions between algae and archaea.Marine life science & technology · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

164 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mohammad R SeyedsayamdostDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Rebecca J Case
Roberto Kolter
Jon Clardy
Harvard University · US

Funding

MOLECULAR GENETICS OF BIOFILM FORMATIONR01GM058213 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RUDNER, DAVID Z · 1998 to 2017
$7.5M
Molecule-to-gene approaches to new natural productsR01GM086258 · NIGMS · HARVARD MEDICAL SCHOOL · PI CLARDY, JON · 2008 to 2016
$3.6M
Chemical Biology of Mircobial Interspecies SignalingR01GM082137 · NIGMS · HARVARD MEDICAL SCHOOL · PI KOLTER, ROBERTO G. · 2007 to 2015
$3.5M
STRUCTURAL STUDIES ON BIOACTIVE NATURAL PRODUCTSR01CA024487 · NCI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI CLARDY, JON · 1985 to 2009
$3.4M
Molecular Analysis of Metabolites and Signaling Networks in Microbial SymbiosesR00GM098299 · NIGMS · PRINCETON UNIVERSITY · PI SEYEDSAYAMDOST, MOHAMMAD R · 2013 to 2015
$747k
Molecular Analysis of Metabolites and Signaling Networks in Microbial SymbiosesK99GM098299 · NIGMS · HARVARD MEDICAL SCHOOL · PI SEYEDSAYAMDOST, MOHAMMAD R · 2011 to 2012
$135k
NCI NIH HHS CA24487NCI NIH HHS R01 CA024487NIGMS NIH HHS GM086258NIGMS NIH HHS GM58213NIGMS NIH HHS GM82137NIGMS NIH HHS K99 GM098299NIGMS NIH HHS R00 GM098299NIGMS NIH HHS R01 GM058213NIGMS NIH HHS R01 GM082137NIGMS NIH HHS R01 GM086258
6 · The paper itself

Abstract

Emiliania huxleyi, an environmentally important marine microalga, has a bloom-and-bust lifestyle in which massive algal blooms appear and fade. Phaeobacter gallaeciensis belongs to the roseobacter clade of α-Proteobacteria, the populations of which wax and wane with that of E. huxleyi. Roseobacter are thought to promote algal growth by biosynthesizing and secreting antibiotics and growth stimulants (auxins). Here we show that P. gallaeciensis switches its secreted small molecule metabolism to the production of potent and selective algaecides, the roseobacticides, in response to p-coumaric acid, an algal lignin breakdown product that is symptomatic of aging algae. This switch converts P. gallaeciensis into an opportunistic pathogen of its algal host.

Indexed as

BacteriaBacterial ToxinsBiosynthetic PathwaysCell ProliferationCoumaric AcidsCrystallography, X-RayHaptophytaInhibitory Concentration 50Magnetic Resonance SpectroscopyMass SpectrometryMicroalgaeModels, BiologicalMolecular ConformationMolecular StructurePropionatesRoseobacterBacterial ToxinsCoumaric Acidsp-coumaric acidPropionates

Identifiers

PMID21430694
PMCPMC3376411
OpenAlexW2040412286

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.