Evidence map›Paper›PMID 21430655›Full record

ReviewMucosal immunology2011

Role of innate cytokines in mycobacterial infection.

A M Cooper, K D Mayer-Barber, A Sher

Open access · bronzeAbstract readReview
In one paragraph

Review in Mucosal immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 1 pooled it
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 1 synthesis or guideline pooled it, 290 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Interleukin-6 fromMicrobiology spectrum · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Inhalational Delivery ofAdvanced therapeutics · 2025
    Article
  16. Article
  17. Article
  18. IFN-γ-Driven macrophage responses in the immunity toFrontiers in cellular and infection microbiology · 2025
    Review
  19. Article
  20. Article

86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

A M CooperTrudeau Institute, Saranac Lake, New York, USA. acooper@trudeauinstitute.org
K D Mayer-Barber
A Sher
National Institutes of Health · USTrudeau Institute · US

Funding

T cell memory to TB in the lungP01AI046530 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SWAIN, SUSAN L · 1999 to 2013
$22.2M
Innate Determinants of Microbial ImmunityZIAAI001044 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SHER, ALAN · 2009 to 2022
$8.8M
T cell memory to TB in the lungR01AI069121 · NIAID · TRUDEAU INSTITUTE, INC. · PI COOPER, ANDREA M · 2008 to 2012
$2.3M
The role of IL-12p40 in the response of pulmonary dendritic cells to tuberculosisR01AI067723 · NIAID · TRUDEAU INSTITUTE, INC. · PI COOPER, ANDREA M · 2006 to 2010
$2.2M
Intramural NIH HHSNIAID NIH HHS AI46530NIAID NIH HHS AI67723NIAID NIH HHS AI69121NIAID NIH HHS P01 AI046530NIAID NIH HHS R01 AI067723NIAID NIH HHS R01 AI069121
6 · The paper itself

Abstract

Cells of the innate immune system produce cytokines and lipid mediators that strongly influence the outcome of mycobacterial infection. In the case of Mycobacterium tuberculosis, the lung is a critical site for this interaction. Here, we review current information on the role of the major innate cytokine pathways both in controlling initial infection as well as in promoting and maintaining adaptive T-cell responses that mediate host resistance or immunopathology. Understanding this important feature of the host-pathogen interaction can provide major insights into the mechanisms of virulence and can lead to new approaches for immunological intervention in tuberculosis and other mycobacterial diseases.

Indexed as

Adaptive ImmunityCytokinesHost-Pathogen InteractionsHumansImmunity, InnateLungMycobacterium tuberculosisT-LymphocytesTuberculosis, PulmonaryVirulenceCytokines

Identifiers

PMID21430655
PMCPMC3294290
OpenAlexW2087187487

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.