ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2011
The expression of GM-CSF and osteopontin in immunocompetent cells precedes the odontoblast differentiation following allogenic tooth transplantation in mice.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Glomerular epithelial protein-1 promotes reparative dentin formation in vivo.Journal of molecular histology · 2026Article
- Promoting Dentin Bridge Formation Through N-Acetyl-L-Cysteine Application in Rat Molar Pulpotomy: An Experimental Study.Journal of functional biomaterials · 2025Article
- Integrating Phosphate Enhances Biomineralization Effect of Methacrylate Cement in Vital Pulp Treatment with Improved Human Dental Pulp Stem Cells Stimulation.Advanced healthcare materials · 2024Article
- Article
- Early revascularization activates quiescent dental pulp stem cells following tooth replantation in mice.Regenerative therapy · 2023Article
- Expression of Toll-like receptor 2, Dectin-1, and Osteopontin in murine model of pulpitis.Clinical oral investigations · 2023Article
- SVCT2-GLUT1-mediated ascorbic acid transport pathway in rat dental pulp and its effects during wound healing.Scientific reports · 2023Article
- Exploring the impact of oral bacteria remnants on stem cells from the Apical papilla: mineralization potential and inflammatory response.Frontiers in cellular and infection microbiology · 2023Article
- Gene expression analysis of toll like receptor 2 and 4, Dectin-1, Osteopontin and inflammatory cytokines in human dental pulp ex-vivo.BMC oral health · 2022Article
- Role of osteopontin in the process of pulpal healing following tooth replantation in mice.Regenerative therapy · 2022Article
- The Role of Dendritic Cells during Physiological and Pathological Dentinogenesis.Journal of clinical medicine · 2021Review
- Responses of oral-microflora-exposed dental pulp to capping with a triple antibiotic paste or calcium hydroxide cement in mouse molars.Regenerative therapy · 2020Article
- Heterogeneity and Developmental Connections between Cell Types Inhabiting Teeth.Frontiers in physiology · 2017Review
- Dental Pulp Defence and Repair Mechanisms in Dental Caries.Mediators of inflammation · 2015Review
- Upregulation of GM-CSF by TGF-β1 in epithelial mesenchymal transition of human HERS/ERM cells.In vitro cellular & developmental biology. Animal · 2014Article
- The effect of five proteins on stem cells used for osteoblast differentiation and proliferation: a current review of the literature.Cellular and molecular life sciences : CMLS · 2014Review
- Responses of BrdU label-retaining dental pulp cells to allogenic tooth transplantation into mouse maxilla.Histochemistry and cell biology · 2011Article
- Effect of calcium hydroxide and adipose-derived stem cell conditioned medium (ADSCs-CM) combination on reparative dentin formation in Wistar rats through RUNX-2 and OPN expression.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental pulp elaborates both bone and dentin under pathological conditions such as tooth replantation/transplantation. This study aims to clarify the expression of granulocyte macrophage colony-stimulating factor (GM-CSF) and osteopontin (OPN) in the process of reparative dentin formation by allogenic tooth transplantation using in situ hybridization for OPN and immunohistochemistry for GM-CSF and OPN at both levels of light and electron microscopes. Following the extraction of the mouse molar, the roots and pulp floor were resected and immediately allografted into the sublingual region. On days 1 to 3, immunocompetent cells such as macrophages and dendritic cells expressed both GM-CSF and OPN, and some of them were arranged along the pulp-dentin border and extended their cellular processes into the dentinal tubules. On days 5 to 7, tubular dentin formation commenced next to the preexisting dentin at the pulp horn where nestin-positive odontoblast-like cells were arranged. Until day 14, bone-like tissue formation occurred in the pulp chamber, where OPN-positive osteoblasts surrounded the bone matrix. These results suggest that the secretion of GM-CSF and OPN by immunocompetent cells such as macrophages and dendritic cells plays a role in the maturation of dendritic cells and the differentiation of odontoblasts, respectively, in the regenerated pulp tissue following tooth transplantation.
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