ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2011
Immunoglobulin g (IgG) expression in human umbilical cord endothelial cells.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- B-cells and non-B-cells immunoglobulins expression in canine perianal gland tumours: a preliminary study.Frontiers in veterinary science · 2025Article
- Spatial transcriptomics reveals prognosis-associated cellular heterogeneity in the papillary thyroid carcinoma microenvironment.Clinical and translational medicine · 2024Article
- Oocytes could rearrange immunoglobulin production to survive over adverse environmental stimuli.Frontiers in immunology · 2022Article
- Immune Cells and Immunoglobulin Expression in the Mammary Gland Tumors of Dog.Animals : an open access journal from MDPI · 2021Article
- Single-cell RNA sequencing confirms IgG transcription and limited diversity of VScientific reports · 2020Article
- Limited Neonatal Carbohydrate-Specific Antibody Repertoire Consecutive to Partial Prenatal Transfer of Maternal Antibodies.Frontiers in immunology · 2020Article
- Single-Cell Transcriptomics of a Human Kidney Allograft Biopsy Specimen Defines a Diverse Inflammatory Response.Journal of the American Society of Nephrology : JASN · 2018Review
- Expression of immunoglobulin G in human podocytes, and its role in cell viability and adhesion.International journal of molecular medicine · 2018Article
- Expression of combinatorial immunoglobulins in macrophages in the tumor microenvironment.PloS one · 2018Article
- [Effect of androgen receptor on IgG expression, proliferation and migration of prostate cancer cells in vitro].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Baofukang suppository promotes the repair of vaginal epithelial cells in response to Candida albicans.AMB Express · 2016Article
- Identification of Liver Epithelial Cell-derived Ig Expression in μ chain-deficient mice.Scientific reports · 2016Article
- Fab fragment glycosylated IgG may play a central role in placental immune evasion.Human reproduction (Oxford, England) · 2015Article
- IgG and IgA with potential microbial-binding activity are expressed by normal human skin epidermal cells.International journal of molecular sciences · 2015Article
- IgG expression in trophoblasts derived from placenta and gestational trophoblastic disease and its role in regulating invasion.Immunologic research · 2014Article
- Cancer-derived immunoglobulin G promotes tumor cell growth and proliferation through inducing production of reactive oxygen species.Cell death & disease · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditional views hold that immunoglobulin G (IgG) in the human umbilical cord is internalized by human umbilical endothelial cells for passive immunity. In this study, the protein and mRNA transcripts of IgG were found in the cytoplasm of human umbilical endothelial cells by immunohistochemistry, in situ hybridization, and reverse transcription PCR (RT-PCR). The essential enzymes for IgG synthesis and assembling, RAG1 (recombination activating gene 1), RAG2, and variable (V), diversity (D), and joining (J) segments for recombination of IgG, were also found in these cells by RT-PCR and real-time PCR. These results indicate that umbilical endothelial cells are capable of synthesizing IgG with properties similar to those of immune cells and that they may play additional roles besides lining the vessels and transporting IgG.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.