ArticleThe Journal of nutrition2011
Parenteral administration of L-arginine enhances fetal survival and growth in sheep carrying multiple fetuses.
Article in The Journal of nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 127 citations in OpenAlex.
- Rumenomics: evaluation of rumen metabolites from healthy sheep identifies differentially produced metabolites across sex, age, and weight.Animal microbiome · 2026Article
- Nutritional Regulation of Reproductive Physiology in Ruminants: A Mechanistic Review.Life (Basel, Switzerland) · 2026Review
- Placental adaptation to maternal environment in domestic animals.The Journal of reproduction and development · 2026Review
- Use of melatonin plus citrulline or arginine to mitigate ergot alkaloid-induced vasoconstriction in sheep.Animal feed science and technology · 2025Article
- Effect of N-Carbamylglutamate Supplementation in Late Pregnancy on Nutrient-Restricted Twin-Bearing Ewes on the Pre-Lambing Maternal Metabolome, Colostrum Quality and Lamb Birth Weight.Animals : an open access journal from MDPI · 2025Article
- Dietary Supplementation with L-Citrulline Between Days 1 and 60 of Gestation Enhances Embryonic Survival in Lactating Beef Cows.Animals : an open access journal from MDPI · 2025Article
- Impact of dietary supplementation of L-citrulline to meat goats during gestation on reproductive performance.Journal of animal science and biotechnology · 2025Article
- Article
- The Effect of N-Carbamylglutamate Supplementation during the Last Third of Gestation on the Growth and Development of Fetuses Born to Nutrient-Restricted Twin-Bearing Ewes.Animals : an open access journal from MDPI · 2024Article
- Resveratrol and β-hydroxy-β-methylbutyric acid supplementation promotes ileal development and digestive function by altering microbial community abundance and metabolites in Tibetan sheep.Frontiers in veterinary science · 2024Article
- Metabolomics-based study of the effect of dietary N-carbamoylglutamic acid addition to heifers in late pregnancy on newborn calves.Frontiers in veterinary science · 2024Article
- Four Markers Useful for the Distinction of Intrauterine Growth Restriction in Sheep.Animals : an open access journal from MDPI · 2023Article
- Oral Administration ofVeterinary medicine international · 2023Article
- Potential benefits of amino acid supplementation for cervid performance and nutritional ecology, with special focus on lysine and methionine: A review.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- Dietary supplementation with monosodium glutamate enhances milk production by lactating sows and the growth of suckling piglets.Amino acids · 2022Article
- Predictive blood biomarkers of sheep pregnancy and litter size.Scientific reports · 2022Article
- Dietary supplementation with branched-chain amino acids enhances milk production by lactating sows and the growth of suckling piglets.Journal of animal science and biotechnology · 2022Article
- DietaryAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Nutrition and Metabolism: Foundations for Animal Growth, Development, Reproduction, and Health.Advances in experimental medicine and biology · 2022Article
- L-Arginine Nutrition and Metabolism in Ruminants.Advances in experimental medicine and biology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The frequency of multiple fetuses has increased in human pregnancies due to assisted reproductive technologies. This translates into a greater proportion of premature and low-birth weight infants in the United States and worldwide. In addition, improvements in sheep breeding have resulted in new breeds with increased litter size but reduced fetal survival and birth weight. Currently, there are no treatments for preventing fetal growth restriction in humans or sheep (an established model for studying human fetal physiology) carrying multiple fetuses. In this work, Booroola Rambouillet ewes (FecB+/-) with 2-4 fetuses were fed a diet providing 100% of NRC-recommended nutrient requirements. Between d 100 and 121 of gestation, ewes received an i.v. bolus injection of either saline solution or 345 μmol arginine-HCl/kg body weight 3 times daily. The arginine treatment reduced (P < 0.05) the percentage of lambs born dead by 23% while increasing (P = 0.05) the percentage of lambs born alive by 59%. The i.v. administration of arginine enhanced (P < 0.05) the birth weights of quadruplets by 23% without affecting maternal body weight. The improved pregnancy outcome was associated with an increase in maternal plasma concentrations of arginine, ornithine, cysteine, and proline, as well as a decrease in circulating levels of ammonia and β-hydroxybutyrate. These novel results indicate that parenteral administration of arginine to prolific ewes ameliorated fetal mortality and growth retardation. Our findings provide support for experiments to assess the clinical use of arginine to enhance fetal growth and survival in women gestating multiple fetuses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.