ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Analysis of the role of IL-21 in development of murine B cell progenitors in the bone marrow.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- The aged microenvironment impairs BCL6 and CD40L induction in CD4Aging cell · 2024Article
- Gm40600 promotes CD4Immunology · 2021Article
- A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease.The EMBO journal · 2019Article
- Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus.Nature communications · 2018Article
- Interleukin-21 promotes thymopoiesis recovery following hematopoietic stem cell transplantation.Journal of hematology & oncology · 2017Article
- Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing.Nature cell biology · 2016Article
- The Biological Effects of IL-21 Signaling on B-Cell-Mediated Responses in Organ Transplantation.Frontiers in immunology · 2016Review
- A pathogenetic role for IL-21 in primary Sjögren syndrome.Nature reviews. Rheumatology · 2015Article
- IL-21 acts as a promising therapeutic target in systemic lupus erythematosus by regulating plasma cell differentiation.Cellular & molecular immunology · 2015Review
- Hrd1-mediated BLIMP-1 ubiquitination promotes dendritic cell MHCII expression for CD4 T cell priming during inflammation.The Journal of experimental medicine · 2014Article
- Extension of the germinal center stage of B cell development promotes autoantibodies in BXD2 mice.Arthritis and rheumatism · 2013Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
IL-21 plays a key role in the late stage of B cell development, where it has been shown to induce growth and differentiation of mature B cells into Ig-secreting plasma cells. Because IL-21R has also been reported on bone marrow (BM) B cell progenitors, we investigated whether IL-21R influenced earlier stages of B cell development. IL-21R is functional as early as the pro-B cell stage, and the strength of receptor-mediated signaling increases as cells mature. The addition of IL-21 to B cell progenitors in cell culture resulted in the accelerated appearance of mature B cell markers and was associated with the induction of Aid, Blimp1, and germline transcripts. We also found that stimulation of both IL-21R and CD40 was sufficient to induce the maturation of early B cell progenitors into IgM- and IgG-secreting cells. Consistent with a role for IL-21 in promoting B cell differentiation, the number of B220(+)CD43(+)IgM(-) pro-B cells was increased, and the number of mature IgM(hi)IgD(hi) cells was decreased in BM of IL-21R-deficient mice. We also report in this paper that IL-21 is expressed by BM CD4(+) T cells. These results provide evidence that IL-21R is functional in B cell progenitors and indicate that IL-21 regulates B cell development.
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