ArticleAmerican journal of epidemiology2011
Placental abruption and perinatal mortality with preterm delivery as a mediator: disentangling direct and indirect effects.
Article in American journal of epidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review.American journal of perinatology · 2017Pooled it
- A New Severity Index for Placental Abruption Predicts Recurrence Risk in Future Pregnancies.Journal of clinical medicine · 2026Article
- Association between small-for-gestational-age at birth and placental abruption in normotensive pregnancies: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Cardiovascular Disease in Singleton Offspring Born of Pregnancies Complicated by Placental Abruption: A Population-Based Retrospective Cohort Study.Journal of the American Heart Association · 2026Article
- Placental Abruption, Preterm Delivery, and Cardiovascular Disease in Twin Offspring.Journal of the American Heart Association · 2026Article
- Placental Abruption and Perinatal Mortality: Abnormal Placentation and Spontaneous Abortion as Contributors to Left Truncation Bias.Paediatric and perinatal epidemiology · 2026Article
- Familial risk of placental abruption.European journal of obstetrics, gynecology, and reproductive biology · 2026Article
- Preterm placental abruption and its association with adverse maternal and neonatal outcomes: a retrospective study.BMC pregnancy and childbirth · 2025Article
- Causal effects of competing obstetrical interventions: mediators of placental abruption and perinatal mortality.American journal of epidemiology · 2025Article
- Relationship Between Heated Tobacco Products and Placental Abruption: A Prospective Cohort Study Using Online Questionnaire.Journal of epidemiology and global health · 2025Article
- Determinants of retroplacental hematoma at the Maradi mother and child health center, Niger: a case‒control study.BMC pregnancy and childbirth · 2024Article
- Placental abruption and perinatal mortality in twins: novel insight into management at preterm versus term gestations.European journal of epidemiology · 2024Article
- Effect of access to antenatal care on risk of preterm birth among migrant women in Italy: A population-based cohort study.Heliyon · 2024Article
- Risks of Placental Abruption and Preterm Delivery in Patients Undergoing Assisted Reproduction.JAMA network open · 2024Article
- Is the long-term poor prognosis of acute myocardial infarction in patients with mental illness mediated through their poor adherence with recommended healthcare?European journal of public health · 2024Article
- Frailty mediating the causality between leucocyte telomere length and mortality: a cohort study of 440,551 UK Biobank participants.The EPMA journal · 2024Article
- Prenatal Exposure to Opioids and Neurodevelopmental Disorders in Children: A Bayesian Mediation Analysis.American journal of epidemiology · 2024Article
- Maternal anaemia during early pregnancy and the risk of neonatal outcomes: a prospective cohort study in Central China.BMJ paediatrics open · 2024Article
- Biomarkers at 6 weeks' gestation in the prediction of early miscarriage in pregnancy following assisted reproductive technology.Acta obstetricia et gynecologica Scandinavica · 2023Article
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Abstract
The authors use recent methodology in causal inference to disentangle the direct and indirect effects that operate through a mediator in an exposure-response association paradigm. They demonstrate how total effects can be partitioned into direct and indirect effects even when the exposure and mediator interact. The impact of bias due to unmeasured confounding on the exposure-response association is assessed through a series of sensitivity analyses. These methods are applied to a problem in perinatal epidemiology to examine the extent to which the effect of abruption on perinatal mortality is mediated through preterm delivery. Data on over 26 million US singleton births (1995-2002) were utilized. Risks of mortality among abruption and nonabruption births were 102.7 and 6.2 per 1,000 births, respectively. Risk ratios of the natural direct and indirect (preterm delivery-mediated) effects of abruption on mortality were 10.18 (95% confidence interval: 9.80, 10.58) and 1.35 (95% confidence interval: 1.33, 1.38), respectively. The proportion of increased mortality risk mediated through preterm delivery was 28.1%, with even higher proportions associated with deliveries at earlier gestational ages. Sensitivity analyses underscore that the qualitative conclusions of some mediated effects and substantial direct effects are reasonably robust to unmeasured confounding of a fairly considerable magnitude.
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