ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Organization of functional synaptic connections between medullary reticulospinal neurons and lumbar descending commissural interneurons in the neonatal mouse.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 34 citations in OpenAlex.
- Lumbar spinal Shox2 interneurons receive monosynaptic excitatory input from the lateral paragigantocellular nucleus in mouse.iScience · 2026Article
- The diversity and plasticity of descending motor pathways rewired after stroke and trauma in rodents.Frontiers in neural circuits · 2025Review
- Excitatory and Inhibitory Descending Commissural Interneurons Differentially Integrate Supraspinal and Segmental Sensory Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Deconstructing the modular organization and real-time dynamics of mammalian spinal locomotor networks.Nature communications · 2023Article
- Crossed activation of thoracic trunk motoneurons by medullary reticulospinal neurons.Journal of neurophysiology · 2019Article
- Glutamatergic neurons of the gigantocellular reticular nucleus shape locomotor pattern and rhythm in the freely behaving mouse.PLoS biology · 2019Article
- Hindbrain V2a Neurons Pattern Rhythmic Activity of Motor Neurons in a Reticulospinal Coculture.Frontiers in neuroscience · 2019Article
- Brainstem Steering of Locomotor Activity in the Newborn Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Parallel descending dopaminergic connectivity of A13 cells to the brainstem locomotor centers.Scientific reports · 2018Article
- Reticulospinal Systems for Tuning Motor Commands.Frontiers in neural circuits · 2018Review
- Diversity of molecularly defined spinal interneurons engaged in mammalian locomotor pattern generation.Journal of neurophysiology · 2017Review
- Computational modeling of spinal circuits controlling limb coordination and gaits in quadrupeds.eLife · 2017Article
- Monoamine Release in the Cat Lumbar Spinal Cord during Fictive Locomotion Evoked by the Mesencephalic Locomotor Region.Frontiers in neural circuits · 2017Article
- Integration of Descending Command Systems for the Generation of Context-Specific Locomotor Behaviors.Frontiers in neuroscience · 2017Review
- Pontine reticulospinal projections in the neonatal mouse: Internal organization and axon trajectories.The Journal of comparative neurology · 2016Article
- A Neonatal Mouse Spinal Cord Compression Injury Model.Journal of visualized experiments : JoVE · 2016Article
- Article
- Segmental organization of vestibulospinal inputs to spinal interneurons mediating crossed activation of thoracolumbar motoneurons in the neonatal mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Organization of pontine reticulospinal inputs to motoneurons controlling axial and limb muscles in the neonatal mouse.Journal of neurophysiology · 2014Article
- Functional subpopulations of V3 interneurons in the mature mouse spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The medullary reticular formation (MRF) of the neonatal mouse is organized so that the medial and lateral MRF activate hindlimb and trunk motoneurons (MNs) with differential predominance. The goal of the present study was to investigate whether this activation is polysynaptic and mediated by commissural interneurons with descending axons (dCINs) in the lumbar spinal cord. To this end, we tested the polysynapticity of inputs from the MRF to MNs and tested for the presence of selective inputs from medial and lateral MRF to 574 individual dCINs in the L2 segment of the neonatal mouse. Reticulospinal-mediated postsynaptic Ca(2+) responses in MNs were reduced in the presence of mephenesin and after a midline lesion, suggesting the involvement of dCINs in mediating the responses. Consistent with this, stimulation of reticulospinal neurons in the medial or lateral MRF activated 51% and 57% of ipsilateral dCINs examined (255 and 352 dCINs, respectively) and 52% and 46% of contralateral dCINs examined (166 and 133 dCINs, respectively). The proportion of dCINs that responded specifically to stimulation of medial or lateral MRF was similar to the proportions of dCINs that responded to both MRF regions or to neither. The three responsive dCIN populations had largely overlapping spatial distributions. We demonstrate the existence of dCIN subpopulations sufficient to mediate responses in lumbar motoneurons from reticulospinal pathways originating from the medial and lateral MRF. Differential control of trunk and hindlimb muscles by the medullary reticulospinal system may therefore be mediated in part by identifiable dCIN populations.
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