ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
An RNA interference-based screen of transcription factor genes identifies pathways necessary for sensory regeneration in the avian inner ear.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Reproductive-state dependent changes in inner ear gene expression in female plainfin midshipman fish.PloS one · 2026Article
- Hair Cell Regeneration: From Animals to Humans.Clinical and experimental otorhinolaryngology · 2024Review
- In vitro and in vivo models: What have we learnt about inner ear regeneration and treatment for hearing loss?Molecular and cellular neurosciences · 2022Review
- Regeneration in the Auditory Organ in Cuban and African Dwarf Crocodiles (Frontiers in cell and developmental biology · 2022Article
- Stem Cells and the Bird Cochlea-Where Is Everybody?Cold Spring Harbor perspectives in medicine · 2019Review
- Aminoglycoside Damage and Hair Cell Regeneration in the Chicken Utricle.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Characterization of the Transcriptomes of Lgr5+ Hair Cell Progenitors and Lgr5- Supporting Cells in the Mouse Cochlea.Frontiers in molecular neuroscience · 2017Article
- Sensory hair cell development and regeneration: similarities and differences.Development (Cambridge, England) · 2015Review
- Making sense of Wnt signaling-linking hair cell regeneration to development.Frontiers in cellular neuroscience · 2015Review
- Sensational placodes: neurogenesis in the otic and olfactory systems.Developmental biology · 2014Review
- Gene-expression analysis of hair cell regeneration in the zebrafish lateral line.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The transcriptome of utricle hair cell regeneration in the avian inner ear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Responses to cell loss become restricted as the supporting cells in mammalian vestibular organs grow thick junctional actin bands that develop high stability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Regeneration of mammalian cochlear and vestibular hair cells through Hes1/Hes5 modulation with siRNA.Hearing research · 2013Article
- Generation of hair cells in neonatal mice by β-catenin overexpression in Lgr5-positive cochlear progenitors.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The Transcriptomics to Proteomics of Hair Cell Regeneration: Looking for a Hair Cell in a Haystack.Microarrays (Basel, Switzerland) · 2013Article
- A brief history of hair cell regeneration research and speculations on the future.Hearing research · 2013Review
- CEBPG Exhibits Allele-Specific Expression in Human Bronchial Epithelial Cells.Gene regulation and systems biology · 2013Article
- A dual function for canonical Wnt/β-catenin signaling in the developing mammalian cochlea.Development (Cambridge, England) · 2012Article
- Fgf signaling regulates development and transdifferentiation of hair cells and supporting cells in the basilar papilla.Hearing research · 2012Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Sensory hair cells of the inner ear are the mechanoelectric transducers of sound and head motion. In mammals, damage to sensory hair cells leads to hearing or balance deficits. Nonmammalian vertebrates such as birds can regenerate hair cells after injury. In a previous study, we characterized transcription factor gene expression during chicken hair cell regeneration. In those studies, a laser microbeam or ototoxic antibiotics were used to damage the sensory epithelia (SE). The current study focused on 27 genes that were upregulated in regenerating SEs compared to untreated SEs in the previous study. Those genes were knocked down by siRNA to determine their requirement for supporting cell proliferation and to measure resulting changes in the larger network of gene expression. We identified 11 genes necessary for proliferation and also identified novel interactive relationships between many of them. Defined components of the WNT, PAX, and AP1 pathways were shown to be required for supporting cell proliferation. These pathways intersect on WNT4, which is also necessary for proliferation. Among the required genes, the CCAAT enhancer binding protein, CEBPG, acts downstream of Jun Kinase and JUND in the AP1 pathway. The WNT coreceptor LRP5 acts downstream of CEBPG, as does the transcription factor BTAF1. Both of these genes are also necessary for supporting cell proliferation. This is the first large-scale screen of its type and suggests an important intersection between the AP1 pathway, the PAX pathway, and WNT signaling in the regulation of supporting cell proliferation during inner ear hair cell regeneration.
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