ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Gata2 is required for migration and differentiation of retinorecipient neurons in the superior colliculus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
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- NONO enhances mRNA processing of super-enhancer-associated GATA2 and HAND2 genes in neuroblastoma.EMBO reports · 2023Article
- Virtual ChIP-seq: predicting transcription factor binding by learning from the transcriptome.Genome biology · 2022Article
- PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum.Acta neuropathologica · 2021Article
- Discovery of chemerin as the new chemoattractant of human mesenchymal stem cells.Cell & bioscience · 2021Article
- GATA2 hypomorphism induces chronic myelomonocytic leukemia in mice.Cancer science · 2019Article
- Neuroglobin Expression in the Brain: a Story of Tissue Homeostasis Preservation.Molecular neurobiology · 2019Review
- Identification of SLC20A1 and SLC15A4 among other genes as potential risk factors for combined pituitary hormone deficiency.Genetics in medicine : official journal of the American College of Medical Genetics · 2018Article
- Deficiency of microRNAScience (New York, N.Y.) · 2017Article
- Supernova: A Versatile Vector System for Single-Cell Labeling and Gene Function Studies in vivo.Scientific reports · 2016Article
- Accelerated Evolution of Enhancer Hotspots in the Mammal Ancestor.Molecular biology and evolution · 2016Article
- The emerging role of GATA transcription factors in development and disease.Expert reviews in molecular medicine · 2016Review
- Risk prediction model for epithelial ovarian cancer using molecular markers and clinical characteristics.Journal of ovarian research · 2015Article
- The role of Tal2 and Tal1 in the differentiation of midbrain GABAergic neuron precursors.Biology open · 2013Article
- Article
- Pleiotropic and isoform-specific functions for Pitx2 in superior colliculus and hypothalamic neuronal development.Molecular and cellular neurosciences · 2013Article
- NotI microarrays: novel epigenetic markers for early detection and prognosis of high grade serous ovarian cancer.International journal of molecular sciences · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The superior colliculus (SC)/optic tectum of the dorsal mesencephalon plays a major role in responses to visual input, yet regulation of neuronal differentiation within this layered structure is only partially understood. Here, we show that the zinc finger transcription factor Gata2 is required for normal SC development. Starting at embryonic day 15 (E15) (corresponding to the times at which neurons of the outer and intermediate layers of the SC are generated), Gata2 is transiently expressed in the rat embryonic dorsal mesencephalon within a restricted region between proliferating cells of the ventricular zone and the deepest neuronal layers of the developing SC. The Gata2-positive cells are postmitotic and lack markers of differentiated neurons, but express markers for immature neuronal precursors including Ascl1 and Pax3/7. In utero electroporation with Gata2 small hairpin RNAs at E16 into cells along the dorsal mesencephalic ventricle interferes with their normal migration into the SC and maintains them in a state characterized by retention of Pax3 expression and the absence of mature neuronal markers. Collectively, these findings indicate that Gata2 plays a required role in the transition of postmitotic neuronal precursor cells of the retinorecipient layers of the SC into mature neurons and that loss of Gata2 arrests them at an intermediate stage of differentiation.
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