ArticleClinical and vaccine immunology : CVI2011
Antibody recognition of porcine circovirus type 2 capsid protein epitopes after vaccination, infection, and disease.
Article in Clinical and vaccine immunology : CVI, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 93 citations in OpenAlex.
- Epidemiological and evolutionary analysis of porcine circovirus type 2 within pig populations in central China during 2021-2024.Archives of virology · 2026Article
- Molecular Detection and Phylogenetic Analysis of Selected Viral Pathogens in Wild Boar Populations of Russia.Viruses · 2026Article
- Engineered PCV2 VLPs for Antigen Delivery: A Platform for Next-Generation Veterinary Vaccines.Transboundary and emerging diseases · 2026Review
- Engineering a bivalent nanoparticle vaccine with PCV2 capsid protein and PRRSV epitopes.Journal of nanobiotechnology · 2025Article
- Cellular immune signatures and differences of four porcine circovirus type 2 vaccines to heterologous PCV2d infection.NPJ vaccines · 2025Article
- The Decade of Porcine Circovirus Type 2 (PCV2) in Thailand: Phylodynamic and Molecular Epidemiology.Transboundary and emerging diseases · 2025Article
- Identification of a conserved B-cell epitope on the capsid protein of porcine circovirus type 4.mSphere · 2024Article
- Efficacy evaluation of a bivalent subunit vaccine against classical swine fever virus and porcine circovirus type 2.Scientific reports · 2024Article
- An updated phylogeography and population dynamics of porcine circovirus 2 genotypes: are they reaching an equilibrium?Frontiers in microbiology · 2024Article
- Genetic diversity of porcine circoviruses 2 and 3 circulating among wild boars in the Moscow Region of Russia.Frontiers in veterinary science · 2024Article
- The Prevalence and Genetic Diversity of Porcine Circoviruses (PCVs) during 2017-2023 in Guangdong Province, China.Animals : an open access journal from MDPI · 2023Article
- Phylogenetic Analysis and Serological Investigation of Porcine Circovirus Indicates Frequent Infection with Various Subtypes.International journal of molecular sciences · 2023Article
- Virome of wild rats (Rattus norvegicus) captured far from pig farms in Jiangsu province of China reveals novel porcine circovirus type 2d (PCV2d) sequences.Virology journal · 2023Article
- Investigating the Genetic Evolution of PCV2 and PCV3 across Six Swine Herds in China from 2020 to 2021.Transboundary and emerging diseases · 2023Article
- Survey of porcine circovirus type 2 and parvovirus in swine breeding herds of Colombia.Veterinary medicine and science · 2022Article
- Article
- Molecular genotypic analysis of porcine circovirus type 2 reveals the predominance of PCV2d in Vietnam (2018-2020) and the association between PCV2h, the recombinant forms, and Vietnamese vaccines.Archives of virology · 2022Article
- Article
- Whole-Genome Analysis of Porcine Circovirus Type 2 in Russia.Pathogens (Basel, Switzerland) · 2021Article
- The Isolated in Utero Environment Is Conducive to the Emergence of RNA and DNA Virus Variants.Viruses · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Open reading frame 2 (ORF2) of porcine circovirus type 2 (PCV2) codes for the 233-amino-acid capsid protein (CP). Baculovirus-based vaccines that express only ORF2 are protective against clinical disease following experimental challenge or natural infection. The goal of this study was to identify regions in CP preferentially recognized by sera from experimentally infected and vaccinated pigs and to compare these responses to those of pigs diagnosed with porcine circovirus-associated disease (PCVAD), including porcine multisystemic wasting syndrome (PMWS) and porcine dermatitis and nephropathy syndrome (PDNS). The approach was to react porcine sera with CP polypeptide fragments followed by finer mapping studies using overlapping oligopeptides that covered amino acids 141 to 200. The results showed that vaccinated pigs preferentially recognized only the largest polypeptide fragment, CP(43-233). A subset of experimentally infected pigs and pigs with PDNS showed strong reactivity against a CP oligopeptide, 169-STIDYFQPNNKR-180. Alanine scanning identified Y-173, F-174, Q-175, and K-179 as important for antibody recognition. The results from this study support the notion of PCV2 modulation of immunity, including antibody responses that may represent a precursor for disease. The recognition of CP(169-180) and other polypeptides provides opportunities to devise diagnostic tests for monitoring the immunological effectiveness of vaccination.
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