ArticleDevelopment (Cambridge, England)2011
The pipsqueak-domain proteins Distal antenna and Distal antenna-related restrict Hunchback neuroblast expression and early-born neuronal identity.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- A high-resolution atlas of the brain predicts lineage and birth order underlying neuronal identity.Cell genomics · 2026Article
- Hierarchical diversification of instinctual behavior neurons by lineage, birth order, and sex.bioRxiv : the preprint server for biology · 2025Article
- Castor is a temporal transcription factor that specifies early born central complex neuron identity.Development (Cambridge, England) · 2024Article
- Dan forms condensates in neuroblasts and regulates nuclear architecture and progenitor competence in vivo.Nature communications · 2024Article
- Seven-up acts in neuroblasts to specify adult central complex neuron identity and initiate neuroblast decommissioning.Development (Cambridge, England) · 2024Article
- Seven-up acts in neuroblasts to specify adult central complex neuron identity and initiate neuroblast decommissioning.bioRxiv : the preprint server for biology · 2023Article
- Pipsqueak family genesFrontiers in molecular neuroscience · 2023Article
- The Drosophila homologue of CTIP1 (Bcl11a) and CTIP2 (Bcl11b) regulates neural stem cell temporal patterning.Development (Cambridge, England) · 2022Article
- Review
- Article
- The Hunchback temporal transcription factor establishes, but is not required to maintain, early-born neuronal identity.Neural development · 2017Article
- Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum.Nature communications · 2014Article
- Temporal fate specification and neural progenitor competence during development.Nature reviews. Neuroscience · 2013Review
- Ikaros promotes early-born neuronal fates in the cerebral cortex.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Temporal patterning of neural progenitors in Drosophila.Current topics in developmental biology · 2013Review
- A resource for manipulating gene expression and analyzing cis-regulatory modules in the Drosophila CNS.Cell reports · 2012Article
- Transcriptional selectors, masters, and combinatorial codes: regulatory principles of neural subtype specification.Wiley interdisciplinary reviews. Developmental biologyReview
- Identification of hunchback cis-regulatory DNA conferring temporal expression in neuroblasts and neurons.Gene expression patterns : GEPArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
A fundamental question in brain development is how precursor cells generate a diverse group of neural progeny in an ordered manner. Drosophila neuroblasts sequentially express the transcription factors Hunchback (Hb), Krüppel (Kr), Pdm1/Pdm2 (Pdm) and Castor (Cas). Hb is necessary and sufficient to specify early-born temporal identity and, thus, Hb downregulation is essential for specification of later-born progeny. Here, we show that distal antenna (dan) and distal antenna-related (danr), encoding pipsqueak motif DNA-binding domain protein family members, are detected in all neuroblasts during the Hb-to-Cas expression window. Dan and Danr are required for timely downregulation of Hb in neuroblasts and for limiting the number of early-born neurons. Dan and Danr function independently of Seven-up (Svp), an orphan nuclear receptor known to repress Hb expression in neuroblasts, because Dan, Danr and Svp do not regulate each other and dan danr svp triple mutants have increased early-born neurons compared with either dan danr or svp mutants. Interestingly, misexpression of Hb can induce Dan and Svp expression in neuroblasts, suggesting that Hb might activate a negative feedback loop to limit its own expression. We conclude that Dan/Danr and Svp act in parallel pathways to limit Hb expression and allow neuroblasts to transition from making early-born neurons to late-born neurons at the proper time.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.