ArticleThe Journal of endocrinology2011
5'AMP-activated protein kinase activity is increased in adipose tissue of northern elephant seal pups during prolonged fasting-induced insulin resistance.
Article in The Journal of endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 60 citations in OpenAlex.
- The Genomic Basis of the Svalbard Reindeer's Adaptation to an Extreme Arctic Environment.Genome biology and evolution · 2025Article
- Pseudocannabinoid H4CBD improves glucose response during advanced metabolic syndrome in OLETF rats independent of increase in insulin signaling proteins.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Nutritional Regulation of Mammary Tumor Microenvironment.Frontiers in cell and developmental biology · 2022Review
- Metabolic response of dolphins to short-term fasting reveals physiological changes that differ from the traditional fasting model.The Journal of experimental biology · 2021Article
- Exogenous GLP-1 stimulates TCA cycle and suppresses gluconeogenesis and ketogenesis in late-fasted northern elephant seals pups.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Response of metabolic hormones and blood metabolites to realimentation in rehabilitated harbor seal (Phoca vitulina) pups.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Partial Body Mass Recovery After Caloric Restriction Abolishes Improved Glucose Tolerance in Obese, Insulin Resistant Rats.Frontiers in endocrinology · 2020Article
- Adipose transcriptome analysis provides novel insights into molecular regulation of prolonged fasting in northern elephant seal pups.Physiological genomics · 2018Article
- Chronic AT1 blockade improves glucose homeostasis in obese OLETF rats.The Journal of endocrinology · 2018Article
- Increased sensitivity of thyroid hormone-mediated signaling despite prolonged fasting.General and comparative endocrinology · 2017Article
- Using blubber explants to investigate adipose function in grey seals: glycolytic, lipolytic and gene expression responses to glucose and hydrocortisone.Scientific reports · 2017Article
- Insulin induces a shift in lipid and primary carbon metabolites in a model of fasting-induced insulin resistance.Metabolomics : Official journal of the Metabolomic Society · 2017Article
- Thyroid hormone-stimulated increases in PGC-1α and UCP2 promote life history-specific endocrine changes and maintain a lipid-based metabolism.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Fasting increases the phosphorylation of AMPK and expression of sirtuin1 in muscle of adult male northern elephant seals (Physiological reports · 2017Article
- Proteomic Analysis of Non-depleted Serum Proteins from Bottlenose Dolphins Uncovers a High Vanin-1 Phenotype.Scientific reports · 2016Article
- Glucose delays the insulin-induced increase in thyroid hormone-mediated signaling in adipose of prolong-fasted elephant seal pups.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Maintenance of skeletal muscle energy homeostasis during prolonged wintertime fasting in the raccoon dog (Nyctereutes procyonoides).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Article
- Adiposity and fat metabolism in lactating and fasting northern elephant seals.Advances in nutrition (Bethesda, Md.) · 2014Review
- A review of the multi-level adaptations for maximizing aerobic dive duration in marine mammals: from biochemistry to behavior.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Review
- Prolonged food deprivation increases mRNA expression of deiodinase 1 and 2, and thyroid hormone receptor β-1 in a fasting-adapted mammal.The Journal of experimental biology · 2013Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Northern elephant seals endure a 2- to 3-month fast characterized by sustained hyperglycemia, hypoinsulinemia, and increased plasma cortisol and free fatty acids, conditions often seen in insulin-resistant humans. We had previously shown that adipose Glut4 expression and 5'AMP-activated protein kinase (AMPK) activity increase and plasma glucose decreases in fasting seals suggesting that AMPK activity contributes to glucose regulation during insulin-resistant conditions. To address the hypothesis that AMPK activity increases during fasting-induced insulin resistance, we performed glucose tolerance tests (GTT) on early (n=5) and late (n=8)-fasted seal pups and compared adipose tissue expression of insulin signaling proteins, peroxisome proliferator-activated receptor γ (PPARγ), and AMPK, in addition to plasma adiponectin, leptin, cortisol, insulin, and non-esterified fatty acid (NEFA) levels. Fasting was associated with decreased glucose clearance, plasma insulin and adiponectin, and intracellular insulin signaling, as well as increased plasma cortisol and NEFAs, supporting the suggestion that seals develop insulin resistance late in the fast. The expression of Glut4 and VAMP2 increased (52 and 63% respectively) with fasting but did not change significantly during the GTT. PPARγ and phosphorylated AMPK did not change in the early fasted seals, but increased significantly (73 and 50% respectively) in the late-fasted seals during the GTT. Increased AMPK activity along with the reduction in the activity of insulin-signaling proteins supports our hypothesis that AMPK activity is increased following the onset of insulin resistance. The association between increased AMPK activity and Glut4 expression suggests that AMPK plays a greater role in regulating glucose metabolism in mammals adapted to prolonged fasting than in non-fasting mammals.
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