ReviewBest practice & research. Clinical obstetrics & gynaecology2011
The genetics of pre-eclampsia and other hypertensive disorders of pregnancy.
Review in Best practice & research. Clinical obstetrics & gynaecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05720169 (Fetal, Obstetrics and Reproduction Genomics), which is not on this map. Cited by 101 papers, 11 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fetal, Obstetrics and Reproduction Genomics
Who cites it
101 citing papers in PubMed, 11 syntheses or guidelines pooled it.
- A plethora of laboratory protocols for vitamin D receptor (VDR) gene variants detection: a systematic review of associations with hypertensive disorders of pregnancy.BMC pregnancy and childbirth · 2025Pooled it
- Cadmium Associated Preeclampsia: A Systematic Literature Review of Pregnancy and Birth Outcomes.Biological trace element research · 2025Pooled it
- Association of maternal serum magnesium with pre-eclampsia in African pregnant women: a systematic review and meta-analysis.International health · 2024Pooled it
- Prediction and prevention of late-onset pre-eclampsia: a systematic review.Frontiers in medicine · 2024Pooled it
- Systematic review of the complement components as potential biomarkers of pre-eclampsia: pitfalls and opportunities.Frontiers in immunology · 2024Pooled it
- Environmental contaminants and preeclampsia: a systematic literature review.Journal of toxicology and environmental health. Part B, Critical reviews · 2018Pooled it
- A best practice position statement on the role of the nephrologist in the prevention and follow-up of preeclampsia: the Italian study group on kidney and pregnancy.Journal of nephrology · 2017Guideline
- Associations Between Fetal Imprinted Genes and Maternal Blood Pressure in Pregnancy.Hypertension (Dallas, Tex. : 1979) · 2016Pooled it
- Associations of Angiotensin-Converting Enzyme Insertion/Deletion, Angiotensin II Receptor A1166C, and Endothelial Nitric Oxide Synthase 4b/a Gene Polymorphisms With Pregnancy Hypertensive Disorders: A Meta-Analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2015Pooled it
- Evaluation of association of maternal IL-10 polymorphisms with risk of preeclampsia by A meta-analysis.Journal of cellular and molecular medicine · 2014Pooled it
- Association of plasminogen activator inhibitor-type 1 (-675 4G/5G) polymorphism with pre-eclampsia: systematic review.PloS one · 2013Pooled it
- Magnesium supplementation and preeclampsia in low-income pregnant women - a randomized double-blind clinical trial.BMC pregnancy and childbirth · 2020Trial
- The Role of Vitamin B6 and Folate-Related Pathways Involved in Gut Microbial Composition in the Development of Preeclampsia: Metabolome-Wide Mendelian Randomization Analysis.Health science reports · 2026Article
- Genetic factors in the risk assessment of preeclampsia: a review of recent findings.Molecular biology reports · 2025Review
- Knowledge, attitude and practice of pregnant women towards pre-eclampsia in Chongqing, China.BMJ open · 2025Observational
- Genetic Variants in Preeclampsia During Pregnancy: A Hospital-Based Case-Control Study.Journal of clinical medicine · 2025Article
- Association between Apolipoprotein L1 genetic variants and risk of preeclampsia and preterm birth among U.S. Black women.European journal of obstetrics & gynecology and reproductive biology: X · 2025Article
- Text phrase-mining in identifying and classifying maternal proteins and genes across preeclampsia and similar pathologies.Physiological reports · 2025Article
- Prediction of late-onset preeclampsia using plasma proteomics: a longitudinal multi-cohort study.Scientific reports · 2024Article
- Review
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension is the most frequent medical complication occurring during pregnancy. In this chapter, we aim to address the genetic contribution to these disorders, with specific focus on pre-eclampsia. The pathogenic mechanisms underlying pre-eclampsia remain to be elucidated; however, immune maladaptation, inadequate placental development and trophoblast invasion, placental ischaemia, oxidative stress and thrombosis are all thought to represent key factors in the development of disease. Furthermore, all of these components have genetic factors that may be involved in the pathogenic changes occurring. The familial nature of pre-eclampsia has been known for many years and, as such, extensive genetic research has been carried out in this area using strategies that include candidate gene studies and linkage analysis. Interactions between fetal and maternal genotypes, the effect of environmental factors, and epistasis will also be considered.
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