ArticleSeminars in arthritis and rheumatism2011
Determinants of work disability in patients with systemic sclerosis: a longitudinal study of the GENISOS cohort.
Article in Seminars in arthritis and rheumatism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Factors Associated with Employment in a Cohort of Patients with Systemic Sclerosis.Journal of clinical medicine · 2025Article
- Prevalence and Outcomes of Gastrointestinal Manifestations in an Australian Scleroderma Cohort.Arthritis care & research · 2024Article
- Within-person fluctuations of fatigue in patients with a clinical diagnosis of systemic sclerosis and its relationship with mood, pain, sleep and physical activity.Journal of scleroderma and related disorders · 2024Article
- Work Productivity and Economic Burden of Systemic Sclerosis in a Multiethnic Asian Population.Arthritis care & research · 2022Article
- Direct and indirect costs of systemic sclerosis and associated interstitial lung disease: A nationwide population-based cohort study.Respirology (Carlton, Vic.) · 2022Article
- Patient-Reported Outcome Measures in Takayasu Arteritis: A Systematic Review and Meta-Analysis.Rheumatology and therapy · 2021Review
- Fatigue Predicts Future Reduced Social Participation, not Reduced Physical Function or Quality of Life in People with Systemic Sclerosis.Journal of scleroderma and related disorders · 2021Article
- Fatigue and Its Association With Social Participation, Functioning, and Quality of Life in Systemic Sclerosis.Arthritis care & research · 2021Article
- Predictors of Hand Contracture in Early Systemic Sclerosis and the Effect on Function: A Prospective Study of the GENISOS Cohort.The Journal of rheumatology · 2019Article
- Extrahepatic Manifestations of Primary Biliary Cholangitis.Gut and liver · 2017Review
- Productivity Losses and Costs in the Less-Common Systemic Autoimmune Rheumatic Diseases.Current rheumatology reports · 2017Review
- Structural Validity of the Rheumatology Attitudes Index in Systemic Sclerosis: Analysis from the UCLA Scleroderma Quality of Life Study.The Journal of rheumatology · 2017Article
- The primary care physician in the early diagnosis of systemic sclerosis: the cornerstone of recognition and hope.The American journal of the medical sciences · 2014Review
- Predictors of fatigue severity in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort.PloS one · 2011Article
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Authors and funding
12 authors.
Funding
Abstract
objectivesTo determine the prevalence, correlates, and predictors of work disability (WD) in the Genetics versus ENvironment In Scleroderma Outcome Study (GENISOS). We hypothesized that WD in systemic sclerosis (SSc) is a function of demographic, clinical, and psychosocial factors.
methodsPatients enrolled in the GENISOS cohort were subdivided in 3 groups: work disabled, working, and retired or homemakers. The latter group (n = 29) was excluded from further analysis. We used logistic regression analysis with a forward hierarchical variable selection strategy to investigate the independent correlates of WD at enrollment. Cox regression proportional Hazard's model with a similar variable selection strategy was utilized to determine the predictors of WD in those working at enrollment.
resultsOverall, 284 patients with a mean age of 48.7 years and disease duration of 2.5 (±1.6) years were enrolled into the GENISOS cohort, consisting of 83.5% female, 46.8% white, 28.9% Hispanic, and 20.4% African American. Patients were longitudinally followed in 1438 study visits. At enrollment, 124 patients (43.7%) were work disabled, whereas 131 (46.1%) were working. Lower level of education (P < 0.001), higher Medsger Lung Severity Index (P = 0.012), higher Fatigue Severity Score (P = 0.008), and less social support (P < 0.001) correlated independently with WD. Of those working at baseline, 35 (26.7%) eventually developed WD. Non-white ethnicity (P = 0.038), lower DLCO % predicted value (P = 0.038), and higher Fatigue Severity Score (P = 0.009) at enrollment independently predicted WD on follow-up visits.
conclusionsWD is a major problem among SSc patients and its prevalence is substantially higher than other rheumatic conditions. Demographic, clinical, and psychosocial factors correlate with WD cross-sectionally and predict WD longitudinally in these patients.
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