ArticleBiological psychiatry2011
Deconstructing craving: dissociable cortical control of cue reactivity in nicotine addiction.
Article in Biological psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed, 59 citations in OpenAlex.
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- Bilateral insular cortical lesions reduce sensitivity to the adverse consequences of acute ethanol intoxication in Pavlovian conditioning procedures.Alcohol, clinical & experimental research · 2024Article
- The anterior insula and its projection to amygdala nuclei modulate the abstinence-exacerbated expression of conditioned place preference.Psychopharmacology · 2024Article
- Still a "hidden island"? The rodent insular cortex in drug seeking, reward, and risk.Neuroscience and biobehavioral reviews · 2023Review
- The intersection of empathy and addiction.Pharmacology, biochemistry, and behavior · 2023Review
- Better living through understanding the insula: Why subregions can make all the difference.Neuropharmacology · 2021Review
- Abnormal white matter tracts of insula in smokers.Brain imaging and behavior · 2021Article
- Prenatal opioid exposure is associated with smaller brain volumes in multiple regions.Pediatric research · 2021Article
- Early Life Stress Promotes Heroin Seeking But Does Not Alter the Excitability of Insular Pyramidal Cells Targeting the Nucleus Accumbens.Frontiers in behavioral neuroscience · 2021Article
- Temporal Dynamics of Large-Scale Networks Predict Neural Cue Reactivity and Cue-Induced Craving.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Anterior insula stimulation suppresses appetitive behavior while inducing forebrain activation in alcohol-preferring rats.Translational psychiatry · 2020Article
- Chemogenetic Stimulation and Silencing of the Insula, Amygdala, Nucleus Accumbens, and Their Connections Differentially Modulate Alcohol Drinking in Rats.Frontiers in behavioral neuroscience · 2020Article
- Continuous High Frequency Deep Brain Stimulation of the Rat Anterior Insula Attenuates the Relapse Post Withdrawal and Strengthens the Extinction of Morphine Seeking.Frontiers in psychiatry · 2020Article
- Structural Imaging-Based Biomarkers for Detecting Craving and Predicting Relapse in Subjects With Methamphetamine Dependence.Frontiers in psychiatry · 2020Article
- Impaired learning from punishment of errors in smokers: Differences in dorsolateral prefrontal cortex and sensorimotor cortex blood-oxygen-level dependent responses.NeuroImage. Clinical · 2019Article
- The Insula: A Brain Stimulation Target for the Treatment of Addiction.Frontiers in pharmacology · 2019Review
- Molecular Histochemistry Identifies Peptidomic Organization and Reorganization Along Striatal Projection Units.Biological psychiatry · 2016Article
- Insula reactivity to negative stimuli is associated with daily cigarette use: A preliminary investigation using the Human Connectome Database.Drug and alcohol dependence · 2016Article
- Differential Involvement of the Agranular vs Granular Insular Cortex in the Acquisition and Performance of Choice Behavior in a Rodent Gambling Task.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Negative affective states and cognitive impairments in nicotine dependence.Neuroscience and biobehavioral reviews · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCue reactivity, the ability of cues associated with addictive substances to induce seeking and withdrawal, is a major contributor to addiction. Although human imaging studies show that cigarette-associated cues simultaneously activate the insula and the orbitofrontal cortex and evoke craving, how these activities functionally contribute to distinct elements of cue reactivity remains unclear. Moreover, it remains unclear whether the simultaneous activation of these cortical regions reflects coordinated functional connectivity or parallel processing.
methodsWe selectively lesioned the insula or orbitofrontal cortex with the excitotoxin ibotenic acid in mice, and their approach to nicotine-associated cues (n = 6-13/group) and avoidance of withdrawal-associated cues (n = 5-12/group) were separately examined in place conditioning paradigms. We additionally tested the role of these two cortical structures in approach to food-associated cues (n = 6-7/group) and avoidance of lithium chloride-associated cues (n = 6-7/group).
resultsOur data show a double dissociation in which excitotoxic lesions of the insula and orbitofrontal cortex selectively disrupted nicotine-induced cue approach and withdrawal-induced cue avoidance, respectively. These effects were not entirely generalized to approach to food-associated cues or avoidance of lithium chloride-associated cues.
conclusionsOur data provide functional evidence that cue reactivity seen in addiction includes unique neuroanatomically dissociable elements and suggest that the simultaneous activation of these two cortical regions in response to smoking-related cues does not necessarily indicate functional connectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.