Evidence map›Paper›PMID 21429234›Full record

Trial reportBMC public health2011

Feasibility of a lifestyle intervention in early pregnancy to prevent deterioration of glucose tolerance.

Eeva A L Korpi-Hyövälti, David E Laaksonen, Ursula S Schwab, Tarja H Vanhapiha, Kristiina R Vihla, Seppo T Heinonen, Leo K Niskanen

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC public health, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01130012 (Feasibility of a Lifestyle Intervention in Early Risk Pregnancy in Preventing Deterioration in Glucose Tolerance?), which is not on this map. Cited by 23 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 6 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01130012 nacompletednot on this map

Feasibility of a Lifestyle Intervention in Early Risk Pregnancy in Preventing Deterioration in Glucose Tolerance?

TypeinterventionalSponsorKuopio University HospitalRan2005 to 2006Enrolled440ConditionsGestational DiabetesArmsLifestyle: diet and exercise, Close follow-up: reporting diaries of food and exercise
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 6 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
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  6. Interventions for preventing excessive weight gain during pregnancy.The Cochrane database of systematic reviews · 2012
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  15. Observational
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  20. Can we modify the intrauterine environment to halt the intergenerational cycle of obesity?International journal of environmental research and public health · 2012
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Eeva A L Korpi-HyövältiDepartment of Internal Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland. eeva.korpi-hyovalti@epshp.fi
David E Laaksonen
Ursula S Schwab
Tarja H Vanhapiha
Kristiina R Vihla
Seppo T Heinonen
Leo K Niskanen
Kuopio University Hospital · FIUniversity of Eastern Finland · FISeinäjoki University of Applied Sciences · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn conjunction with the growing prevalence of obesity and the older age of pregnant women gestational diabetes (GDM) is a major health problem.The aim of the study was to evaluate if a lifestyle intervention since early pregnancy is feasible in improving the glucose tolerance of women at a high-risk for GDM in Finland.

methodsA 75-g oral glucose tolerance test (OGTT) was performed in early pregnancy (n = 102). Women at high risk for GDM (n = 54) were randomized at weeks 8-12 from Apr 2005 to May 2006 to a lifestyle intervention group (n = 27) or to a close follow-up group (n = 27). An OGTT was performed again at weeks 26-28 for the lifestyle intervention and close follow-up groups.

resultsThe values of the OGTT during the second trimester did not differ between the lifestyle intervention and close follow-up groups. In the lifestyle intervention group three women had GDM in the second trimester and respectively one woman in the close follow up group. Insulin therapy was not required in both groups. The intervention resulted in somewhat lower weight gain 11.4 ± 6.0 kg vs. 13.9 ± 5.1 kg, p = 0.062, adjusted by the prepregnancy weight.

conclusionsEarly intervention with an OGTT and simple lifestyle advice is feasible. A more intensive lifestyle intervention did not offer additional benefits with respect to glucose tolerance, although it tended to ameliorate the weight gain.

trial registrationClinicalTrials.gov: NCT01130012.

Indexed as

Directive CounselingLife StyleAdultDiabetes, GestationalFeasibility StudiesFemaleFinlandFollow-Up StudiesGlucose IntoleranceGlucose Tolerance TestHumansPregnancyRisk FactorsTime Factors

Identifiers

PMID21429234
PMCPMC3078095
OpenAlexW2040028337

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.