Evidence map›Paper›PMID 21428818›Full record

ReviewFuture medicinal chemistry2011

Use of multicomponent reactions in developing small-molecule tools to study GABAA receptor mechanism and function.

Ryan W Lewis, George P Hess, Bruce Ganem

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Future medicinal chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ryan W LewisDepartment of Molecular Biology & Genetics, Cornell University, Ithaca, NY 14853-2703, USA.
George P Hess
Bruce Ganem
Cornell University · US

Funding

PREDOCTORAL TRAINING IN CELLULAR AND MOLECULAR BIOLOGYT32GM007273 · NIGMS · CORNELL UNIVERSITY ITHACA · PI BRETSCHER, ANTHONY P. · 1985 to 2019
$11.6M
RELATIONSHIPS BETWEEN PROTEIN STRUCTURE AND FUNCTIONR01GM004842 · NIGMS · CORNELL UNIVERSITY ITHACA · PI HESS, GEORGE PAUL · 1985 to 2006
$1.8M
NIGMS NIH HHS 5T32GM7273NIGMS NIH HHS GM 04842NIGMS NIH HHS R01 GM004842NIGMS NIH HHS T32 GM007273
6 · The paper itself

Abstract

We discuss the potential use of multicomponent reactions in developing small-molecule probes of GABA(A) receptor function. Two examples that illustrate this approach are presented: the synthesis of a class of compounds that specifically modulate the function of GABA(A) receptors containing the δ-subunit, and also 'caged' GABA derivatives. A caged GABA is a photolabile precursor of GABA that releases GABA upon photolysis.

Indexed as

gamma-Aminobutyric AcidHEK293 CellsHumansMolecular StructurePhotochemistryPhotolysisPyrimidinonesReceptors, GABA-Agamma-Aminobutyric AcidPyrimidinonesReceptors, GABA-A

Identifiers

PMID21428818
PMCPMC3152297
OpenAlexW2012184046

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.