ArticleBiochemistry2011
Histone methylases MLL1 and MLL3 coordinate with estrogen receptors in estrogen-mediated HOXB9 expression.
Article in Biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Mixed-lineage leukaemia 1 contributes to endometrial stromal cells progesterone responsiveness during decidualization.Journal of cellular and molecular medicine · 2021Article
- HOX Genes Family and Cancer: A Novel Role for Homeobox B9 in the Resistance to Anti-Angiogenic Therapies.Cancers · 2020Review
- Restoration of KMT2C/MLL3 in human colorectal cancer cells reinforces genome-wide H3K4me1 profiles and influences cell growth and gene expression.Clinical epigenetics · 2020Article
- HOXA5 Expression Is Elevated in Breast Cancer and Is Transcriptionally Regulated by Estradiol.Frontiers in genetics · 2020Article
- LncRNA HOTAIR regulates lipopolysaccharide-induced cytokine expression and inflammatory response in macrophages.Scientific reports · 2018Article
- Genomic-Epidemiologic Evidence That Estrogens Promote Breast Cancer Development.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function.Oncogene · 2018Article
- Modes of Interaction of KMT2 Histone H3 Lysine 4 Methyltransferase/COMPASS Complexes with Chromatin.Cells · 2018Review
- The Histone Methyltransferase Mixed Lineage Leukemia (MLL) 3 May Play a Potential Role on Clinical Dilated Cardiomyopathy.Molecular medicine (Cambridge, Mass.) · 2017Article
- Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinctEpigenetics & chromatin · 2017Article
- Article
- Genetic Loci and Novel Discrimination Measures Associated with Blood Pressure Variation in African Americans Living in Tallahassee.PloS one · 2016Article
- LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer.Biochimica et biophysica acta · 2015Review
- Bisphenol-A induces expression of HOXC6, an estrogen-regulated homeobox-containing gene associated with breast cancer.Biochimica et biophysica acta · 2015Article
- Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo.The Journal of steroid biochemistry and molecular biology · 2014Article
- Overexpression of HOXB9 promotes metastasis and indicates poor prognosis in colon cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2014Article
- Article
- Early histone modifications in the ventromedial hypothalamus and preoptic area following oestradiol administration.Journal of neuroendocrinology · 2013Article
- Histone methylase MLL1 has critical roles in tumor growth and angiogenesis and its knockdown suppresses tumor growth in vivo.Oncogene · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Homeobox gene HOXB9 is a critical player in development of mammary gland and sternum and in regulation of renin which is closely linked with blood pressure control. Our studies demonstrated that HOXB9 gene is transcriptionally regulated by estrogen (E2). HOXB9 promoter contains several estrogen-response elements (ERE). Reporter assay based experiments demonstrated that HOXB9 promoter EREs are estrogen responsive. Estrogen receptors ERα and ERβ are essential for E2-mediated transcriptional activation of HOXB9. Chromatin immunoprecipitation assay demonstrated that ERs bind to HOXB9 EREs as a function of E2. Similarly, histone methylases MLL1 and MLL3 also bind to HOXB9 EREs and play a critical role in E2-mediated transcriptional activation of HOXB9. Overall, our studies demonstrated that HOXB9 is an E2-responsive gene and ERs coordinate with MLL1 and MLL3 in E2-mediated transcriptional regulation of HOXB9.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.