ArticleThe EMBO journal2011
β1 integrins regulate fibroblast chemotaxis through control of N-WASP stability.
Article in The EMBO journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Prospects of compounds of herbal plants as anticancer agents: a comprehensive review from molecular pathways.Frontiers in pharmacology · 2024Review
- Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- SSeCKS promoted lipopolysaccharide-sensitized astrocytes migration via increasing β-1,4-galactosyltransferase-I activity.Neurochemical research · 2019Article
- Extracellular matrix promotes clathrin-dependent endocytosis of prolactin and STAT5 activation in differentiating mammary epithelial cells.Scientific reports · 2017Article
- Regulation of circular dorsal ruffles, macropinocytosis, and cell migration by RhoG and its exchange factor, Trio.Molecular biology of the cell · 2017Article
- Myosin phosphorylation on stress fibers predicts contact guidance behavior across diverse breast cancer cells.Biomaterials · 2017Article
- Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes.Nature communications · 2016Article
- Lamellipodia are crucial for haptotactic sensing and response.Journal of cell science · 2016Article
- Identification of a novel regulatory sequence of actin nucleation promoting factor encoded by Autographa californica multiple nucleopolyhedrovirus.The Journal of biological chemistry · 2015Article
- Integrins and epithelial cell polarity.Journal of cell science · 2014Review
- The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42.The Journal of biological chemistry · 2013Article
- Quality-control culture system restores diabetic endothelial progenitor cell vasculogenesis and accelerates wound closure.Diabetes · 2013Article
- Substrate Stiffness Regulates PDGF-Induced Circular Dorsal Ruffle Formation Through MLCK.Cellular and molecular bioengineering · 2013Article
- Migration of cells in a social context.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Integrin-specific control of focal adhesion kinase and RhoA regulates membrane protrusion and invasion.PloS one · 2013Article
- Mechanistic insights into the regulation of circular dorsal ruffle formation.Journal of biochemistry · 2013Review
- WIP regulates persistence of cell migration and ruffle formation in both mesenchymal and amoeboid modes of motility.PloS one · 2013Article
- Functions and regulation of circular dorsal ruffles.Molecular and cellular biology · 2012Review
- Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex.The Journal of cell biology · 2012Article
- Integrin trafficking at a glance.Journal of cell science · 2012Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Chemotactic migration of fibroblasts towards growth factors, such as during development and wound healing, requires precise spatial coordination of receptor signalling. However, the mechanisms regulating this remain poorly understood. Here, we demonstrate that β1 integrins are required both for fibroblast chemotaxis towards platelet-derived growth factor (PDGF) and growth factor-induced dorsal ruffling. Mechanistically, we show that β1 integrin stabilises and spatially regulates the actin nucleating endocytic protein neuronal Wiskott–Aldrich syndrome protein (N-WASP) to facilitate PDGF receptor traffic and directed motility. Furthermore, we show that in intact cells, PDGF binding leads to rapid activation of β1 integrin within newly assembled actin-rich membrane ruffles. Active β1 in turn controls assembly of N-WASP complexes with both Cdc42 and WASP-interacting protein (WIP), the latter of which acts to stabilise the N-WASP. Both of these protein complexes are required for PDGF internalisation and fibroblast chemotaxis downstream of β1 integrins. This represents a novel mechanism by which integrins cooperate with growth factor receptors to promote localised signalling and directed cell motility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.