ArticleAnesthesiology2011
Increased peak postoperative B-type natriuretic peptide predicts decreased longer-term physical function after primary coronary artery bypass graft surgery.
Article in Anesthesiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01258231 (Identification of Genomic Predictors of Adverse Events After Cardiac Surgery), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- The Association of NT-proBNP With Maximum Tongue Pressure After Cardiac Surgery: A Cross-Sectional Study.Journal of oral rehabilitation · 2026Article
- Heart failure is the most negative consequence of CABG surgery (importance of exercise rehabilitation approach).ARYA atherosclerosis · 2025Review
- Impact of high intensity interval and moderate continuous training on plasma ratios of ProBNPFrontiers in physiology · 2023Article
- The frequency of postoperative BNP measurement and intervention threshold of BNP concentration in pediatric cardiac intensive care unit: a prospective multicenter observational study.Journal of anesthesia · 2022Observational
- Soluble neprilysin and survival in critically ill patients.ESC heart failure · 2022Observational
- Relationship between high-sensitivity cardiac troponin T, B-type natriuretic peptide, and physical function in patients with heart failure.ESC heart failure · 2021Article
- Clinical value of NT-proBNP measurements in assessing patients in the pediatric intensive care unit.Translational pediatrics · 2021Article
- Subclinical Cardiovascular Disease and Fall Risk in Older Adults: Results From the Atherosclerosis Risk in Communities Study.Journal of the American Geriatrics Society · 2019Article
- Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors.Critical care (London, England) · 2019Article
- Plasma corin decreases after coronary artery bypass graft surgery and is associated with postoperative heart failure: a pilot study.Journal of cardiothoracic and vascular anesthesia · 2015Observational
- Increased perioperative b-type natriuretic peptide associates with heart failure hospitalization or heart failure death after coronary artery bypass graft surgery.Anesthesiology · 2013Article
- Potential biomarkers for predicting outcomes in CABG cardiothoracic surgeries.Journal of cardiothoracic surgery · 2013Review
- Level of perioperative B-type natriuretic peptide associates with heart function after on-pump coronary artery bypass graft surgery on a beating heart.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundIncreased peak postoperative B-type natriuretic peptide (BNP) is associated with increased major adverse cardiovascular events and all-cause mortality after coronary artery bypass graft (CABG) surgery. Whether increased postoperative BNP predicts worse postdischarge physical function (PF) is unknown. We hypothesized that peak postoperative BNP associates with PF assessed up to 2 yr after CABG surgery, even after adjusting for clinical risk factors. including preoperative PF.
methodsThis two-institution prospective cohort study included patients undergoing primary CABG surgery with cardiopulmonary bypass. Short Form-36 questionnaires were administered to subjects preoperatively and 6 months, 1 yr, and 2 yr postoperatively. Short Form-36 PF domain scores were calculated using the Short Form-36 norm-based scoring algorithm. Plasma BNP concentrations measured preoperatively and on postoperative days 1-5 were log(10) transformed before analysis. To determine whether peak postoperative BNP independently predicts PF scores 6 months through 2 yr after CABG surgery, multivariable longitudinal regression analysis of the postoperative PF scores was performed, adjusting for important clinical risk factors.
resultsA total of 845 subjects (mean ± SD age, 65 ± 10 yr) were analyzed. Peak postoperative BNP was significantly associated with postoperative PF (effect estimate for log(10) peak BNP, -7.66 PF score points [95% CI, -9.68 to -5.64]; P = <0.0001). After multivariable adjustments, peak postoperative BNP remained independently associated with postoperative PF (effect estimate for log(10) peak BNP, -3.06 PF score points [95% CI, -5.15 to -0.97]; P = 0.004).
conclusionsIncreased peak postoperative BNP independently associates with worse longer-term PF after primary CABG surgery. Future studies are needed to determine whether medical management targeted toward reducing increased postoperative BNP can improve PF after CABG surgery.
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Registered trials
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