Evidence map›Paper›PMID 21427401›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2011

Reanalysis of coreceptor tropism in HIV-1-infected adults using a phenotypic assay with enhanced sensitivity.

Timothy J Wilkin, Mathew Bidwell Goetz, Robert Leduc, Gail Skowron, Zhaohui Su, Ellen S Chan, Jayyant Heera, Doug Chapman, John Spritzler, Jacqueline D Reeves and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 47 citations in OpenAlex.

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  20. HIV-1 tropism testing and clinical management of CCR5 antagonists: Quebec review and recommendations.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Timothy J WilkinDivision of Infectious Disease, Weill Cornell Medical College, New York, New York 10011, USA. tiw2001@med.cornell.edu
Mathew Bidwell Goetz
Robert Leduc
Gail Skowron
Zhaohui Su
Ellen S Chan
Jayyant Heera
Doug Chapman
John Spritzler
Jacqueline D Reeves
Roy M Gulick
Eoin Coakley
Cornell University · USHarvard University · USPfizer (United States) · USBoston University · USHealth Outcomes Solutions (United States) · USRoger Williams Medical Center · USUniversity of Minnesota · USVA Greater Los Angeles Healthcare System · US

Funding

Statistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6M
AIDS Clinical Trials Group NetworkU01AI068636 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI KURITZKES, DANIEL R. · 2006 to 2010
$147.1M
International Network for Strategic Initiatives in Global HIV Trials (INSIGHT)U01AI068641 · NIAID · UNIVERSITY OF MINNESOTA · PI NEATON, JAMES DENNIS · 2006 to 2010
$120.1M
COMMUNITY PROGRAMS FOR CLINICAL RESEARCH ON AIDSU01AI046362 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI GORDIN, FRED M · 2000 to 2006
$75.9M
Statistical and Data Management Center for the AIDS Clinical Trials GroupU01AI068634 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI HUGHES, MICHAEL DAVID · 2006 to 2010
$71.9M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024996 · NCRR · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2007 to 2011
$49.6M
Weill Cornell Medicine - Rutgers New Jersey Medical School Clinical Trials UnitUM1AI069419 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROY M. GULICK · 2012 to 2026
$44.6M
TERRY BEIRN COMMUNITY PROGRAMS FOR CLINICAL RESEARCH ONU01AI042170 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI NEATON, JAMES DENNIS · 1997 to 2006
$23.2M
ADULT THERAPEUTIC CLINICAL TRIALS PROGRAM FOR HIV/AIDSU01AI046381 · NIAID · MIRIAM HOSPITAL · PI FLANIGAN, TIMOTHY P · 2000 to 2006
$7.8M
Cornell Clinical Trials UnitU01AI069419 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI GULICK, ROY M. · 2007 to 2011
$6.5M
Antiretroviral Therapy for HIV-Infected PatientsK24AI051966 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI GULICK, ROY M. · 2003 to 2012
$1.6M
Novel assay for measuring HIV-1 replication capacityR44AI050321 · NIAID · MONOGRAM BIOSCIENCES, INC. · PI BATES, MICHAEL P · 2004 to 2005
$1.5M
NCRR NIH HHS RR024996NCRR NIH HHS UL1 RR024996NIAID NIH HHS AI-46381NIAID NIH HHS AI-68634NIAID NIH HHS AI-69419NIAID NIH HHS K23 AI055038NIAID NIH HHS K23 AI55038NIAID NIH HHS K24 AI051966NIAID NIH HHS K24 AI51966NIAID NIH HHS R44 AI050321NIAID NIH HHS R44AI050321NIAID NIH HHS U01 AI042170NIAID NIH HHS U01 AI046362NIAID NIH HHS U01 AI046381NIAID NIH HHS U01 AI068634NIAID NIH HHS U01 AI068636NIAID NIH HHS U01 AI068641NIAID NIH HHS U01 AI069419NIAID NIH HHS U01 AI-42170NIAID NIH HHS U01 AI-46362NIAID NIH HHS U01 AI-68636NIAID NIH HHS U01 AI-68641NIAID NIH HHS UM1 AI068634NIAID NIH HHS UM1 AI069419
6 · The paper itself

Abstract

The enhanced-sensitivity Trofile assay (TF-ES; Monogram Biosciences) was used to retest coreceptor tropism samples from 4 different cohorts of HIV-1-infected patients. Nine percent to 26% of patients with CCR5-tropic virus by the original Trofile assay had CXCR4-using virus by TF-ES. Lower CD4 cell counts were associated with CXCR4-using virus in all cohorts.

Indexed as

Viral TropismVirus AttachmentAdultHIV-1HIV InfectionsHumansReceptors, CCR5Receptors, CXCR4Receptors, HIVVirologyCXCR4 protein, humanReceptors, CCR5Receptors, CXCR4Receptors, HIV

Identifiers

PMID21427401
PMCPMC3106234
OpenAlexW2120558856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.