ArticleEndocrinology2011
Genetic ablation of sfrp4 in mice does not affect serum phosphate homeostasis.
Article in Endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Dampened HPG axis activity and altered ovarian gene transcription in Dummerstorf high-fertility mouse line FL2.Endocrine connections · 2026Article
- The Janus Face of sFRP4 in Cancer: From Mechanistic Complexity to Therapeutic Potential.International journal of molecular sciences · 2026Review
- Potential predictive value of circulating tumor DNA (ctDNA) mutations for the efficacy of immune checkpoint inhibitors in advanced triple-negative breast cancer.Frontiers in genetics · 2023Article
- RNA-sequencing reveals genes linked with oocyte developmental potential in bovine cumulus cells.Molecular reproduction and development · 2022Article
- Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases.Frontiers in endocrinology · 2021Review
- Bisphenol A and bisphenol S disruptions of the mouse placenta and potential effects on the placenta-brain axis.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- SFRP4 Is a Negative Regulator of Ovarian Follicle Development and Female Fertility.Endocrinology · 2019Article
- Role of the Wnt/International journal of endocrinology · 2018Review
- Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cortical-Bone Fragility--Insights from sFRP4 Deficiency in Pyle's Disease.The New England journal of medicine · 2016Article
- Article
- The phosphate transporter NaPi-IIa determines the rapid renal adaptation to dietary phosphate intake in mouse irrespective of persistently high FGF23 levels.Pflugers Archiv : European journal of physiology · 2013Article
- Insights from genetic disorders of phosphate homeostasis.Seminars in nephrology · 2013Review
- WNT signaling in bone homeostasis and disease: from human mutations to treatments.Nature medicine · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Serum phosphate levels are regulated by PTH and the fibroblast growth factor 23 (Fgf23)/Klotho endocrine system, which both affect expression of Npt2a and thus the apical reabsorption of phosphate in the proximal renal tubules. In addition to Fgf23, secreted frizzled-related protein 4 (Sfrp4) has recently been implicated as an additional phosphate regulator in vivo and in vitro. Here we demonstrate that ablation of the Sfrp4 gene in mice does not lead to altered serum or urine phosphate levels. Furthermore, Sfrp4 is unable to compensate for the absence of Fgf23 or Klotho because double knockouts have a similar biochemical profile and phenotype as animals with ablation of Fgf23 or Klotho alone. Taken together, our data suggest that Sfrp4 does not contribute to the long-term regulation of serum phosphate levels in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.