ArticleEndocrinology2011
Tetrahydrobiopterin restores diastolic function and attenuates superoxide production in ovariectomized mRen2.Lewis rats.
Article in Endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Review
- Sex Differences in Cardiovascular Aging and Heart Failure.Current heart failure reports · 2020Review
- Connecting sex differences, estrogen signaling, and microRNAs in cardiac fibrosis.Journal of molecular medicine (Berlin, Germany) · 2019Review
- G protein-coupled estrogen receptor (GPER) deficiency induces cardiac remodeling through oxidative stress.Translational research : the journal of laboratory and clinical medicine · 2018Article
- Cardioprotection Induced by Activation of GPER in Ovariectomized Rats With Pulmonary Hypertension.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- The association of surgical versus natural menopause with future left ventricular structure and function: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.Menopause (New York, N.Y.) · 2017Article
- Effect of Age, Estrogen Status, and Late-Life GPER Activation on Cardiac Structure and Function in the Fischer344×Brown Norway Female Rat.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Acute ascorbic acid infusion increases left ventricular diastolic function in postmenopausal women.Maturitas · 2016Article
- Tetrahydrobiopterin in cardiovascular health and disease.Antioxidants & redox signaling · 2014Review
- Role of estrogen in diastolic dysfunction.American journal of physiology. Heart and circulatory physiology · 2014Review
- Salt loading exacerbates diastolic dysfunction and cardiac remodeling in young female Ren2 rats.Metabolism: clinical and experimental · 2013Article
- Estrogen therapy, independent of timing, improves cardiac structure and function in oophorectomized mRen2.Lewis rats.Menopause (New York, N.Y.) · 2013Article
- Characterization of the cardiac renin angiotensin system in oophorectomized and estrogen-replete mRen2.Lewis rats.PloS one · 2013Article
- Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat.Journal of cardiovascular pharmacology · 2012Article
- Activation of GPR30 attenuates diastolic dysfunction and left ventricle remodelling in oophorectomized mRen2.Lewis rats.Cardiovascular research · 2012Article
- Diastolic function during hemorrhagic shock in rabbits.Molecular and cellular biochemistry · 2012Article
- The Role of Estrogen in Cardiac Metabolism and Diastolic Function.Methodist DeBakey cardiovascular journalReview
- Blunting of cardioprotective actions of estrogen in female rodent heart linked to altered expression of cardiac tissue chymase and ACE2.Journal of the renin-angiotensin-aldosterone system : JRAASArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
After oophorectomy, mRen2.Lewis rats exhibit diastolic dysfunction associated with elevated superoxide, increased cardiac neuronal nitric oxide synthase (nNOS) expression, and diminished myocardial tetrahydrobiopterin (BH₄) content, effects that are attenuated with selective nNOS inhibition. BH₄ is an essential cofactor of nNOS catalytic activity leading to nitric oxide production. Therefore, we assessed the effect of 4 wk BH₄ supplementation on diastolic function and left ventricular (LV) remodeling in oophorectomized mRen2.Lewis rats compared with sham-operated controls. Female mRen2.Lewis rats underwent either bilateral ovariectomy (OVX) (n = 19) or sham operation (n = 13) at 4 wk of age. Beginning at 11 wk of age, OVX rats were randomized to receive either BH₄ (10 mg/kg · d) or saline, whereas the sham rats received saline via sc mini-pumps. Loss of ovarian hormones reduced cardiac BH₄ when compared with control hearts; this was associated with impaired myocardial relaxation, augmented filling pressures, increased collagen deposition, and thickened LV walls. Additionally, superoxide production increased and nitric oxide decreased in hearts from OVX compared with sham rats. Chronic BH₄ supplementation after OVX improved diastolic function and attenuated LV remodeling while restoring myocardial nitric oxide release and preventing reactive oxygen species generation. These data indicate that BH₄ supplementation protects against the adverse effects of ovarian hormonal loss on diastolic function and cardiac structure in mRen2.Lewis rats by restoring myocardial NO release and mitigating myocardial O₂⁻ generation. Whether BH₄ supplementation is a therapeutic option for the management of diastolic dysfunction in postmenopausal women will require direct testing in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.