ArticleNucleic acids research2011
A structural determinant required for RNA editing.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Improved RNA base editing with guide RNAs mimicking highly edited endogenous ADAR substrates.Nature biotechnology · 2026Article
- ADAR-GPT: A continually fine-tuned language model for predicting A-to-I RNA editing sites.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Nucleic acid therapeutics: Past, present, and future.Molecular therapy. Nucleic acids · 2025Review
- Dissecting the basis for differential substrate specificity of ADAR1 and ADAR2.Nature communications · 2023Article
- RNA epitranscriptomics dysregulation: A major determinant for significantly increased risk of ASD pathogenesis.Frontiers in neuroscience · 2023Article
- UncoveringmBio · 2022Article
- Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo.Nature biotechnology · 2022Article
- ADARs act as potent regulators of circular transcriptome in cancer.Nature communications · 2022Article
- Specificity of mRNA Folding and Its Association with Evolutionarily Adaptive mRNA Secondary Structures.Genomics, proteomics & bioinformatics · 2021Article
- RDDSVM: accurate prediction of A-to-I RNA editing sites from sequence using support vector machines.Functional & integrative genomics · 2021Article
- Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis.Nature communications · 2021Article
- Transcription-Associated Mutation Promotes RNA Complexity in Highly Expressed Genes-A Major New Source of Selectable Variation.Molecular biology and evolution · 2018Article
- An Evolutionary Landscape of A-to-I RNA Editome across Metazoan Species.Genome biology and evolution · 2018Article
- Trans and cis factors affecting A-to-I RNA editing efficiency of a noncoding editing target in C. elegans.RNA (New York, N.Y.) · 2016Article
- Review
- RNA editing of microRNA prevents RNA-induced silencing complex recognition of target mRNA.Open biology · 2015Article
- Genetic mapping uncovers cis-regulatory landscape of RNA editing.Nature communications · 2015Article
- Review
- Cis regulatory effects on A-to-I RNA editing in related Drosophila species.Cell reports · 2015Article
- Dynamic response of RNA editing to temperature in Drosophila.BMC biology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
RNA editing by adenosine deaminases acting on RNAs (ADARs) can be both specific and non-specific, depending on the substrate. Specific editing of particular adenosines may depend on the overall sequence and structural context. However, the detailed mechanisms underlying these preferences are not fully understood. Here, we show that duplex structures mimicking an editing site in the Gabra3 pre-mRNA unexpectedly fail to support RNA editing at the Gabra3 I/M site, although phylogenetic analysis suggest an evolutionarily conserved duplex structure essential for efficient RNA editing. These unusual results led us to revisit the structural requirement for this editing by mutagenesis analysis. In vivo nuclear injection experiments of mutated editing substrates demonstrate that a non-conserved structure is a determinant for editing. This structure contains bulges either on the same or the strand opposing the edited adenosine. The position of these bulges and the distance to the edited base regulate editing. Moreover, elevated folding temperature can lead to a switch in RNA editing suggesting an RNA structural change. Our results indicate the importance of RNA tertiary structure in determining RNA editing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.