ArticleZhongguo fei ai za zhi = Chinese journal of lung cancer2011
[DNA methylation of tumor suppressor genes located on chromosome 3p in non-small cell lung cancer].
Article in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 5 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The clinicopathological significance of FHIT hypermethylation in non-small cell lung cancer, a meta-analysis and literature review.Scientific reports · 2016Pooled it
- The clinicopathological significance and ethnic difference of FHIT hypermethylation in non-small-cell lung carcinoma: a meta-analysis and literature review.Drug design, development and therapy · 2016Pooled it
- [Meta-analysis of the Association between RASSF1A Gene Promoter Methylation and Non-small Cell Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2015Pooled it
- [The relationship between FHIT gene promoter methylation and lung cancer risk: a meta-analysis].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2014Pooled it
- A meta-analysis of the relationship between RARβ gene promoter methylation and non-small cell lung cancer.PloS one · 2014Pooled it
- PMEnvironmental health and preventive medicine · 2020Article
- Application of artificial neural network model combined with four biomarkers in auxiliary diagnosis of lung cancer.Medical & biological engineering & computing · 2017Article
- [Research Progress of PR Domain Zinc Finger Protein 14].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2016Review
- DNA methylation of hMLH1 correlates with the clinical response to cisplatin after a surgical resection in Non-small cell lung cancer.International journal of clinical and experimental pathology · 2015Article
- Development of a multiplex methylation specific PCR suitable for (early) detection of non-small cell lung cancer.Epigenetics · 2014Article
- The significance of epigenetic alterations in lung carcinogenesis.Molecular biology reports · 2013Review
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Authors and funding
5 authors.
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Abstract
BACKGROUND AND
objectiveDNA methylation is one of the mechanisms of epigenetics. Allelic loss located on chromosome 3p happen frequently and early in non-small cell lung cancer (NSCLC). The aim of this study is to detect the promoter methylation status of tumor suppressor genes (TSGs) located on chromosome 3p in NSCLC and to evaluate its correlation with clinicopathological features.
methodsA total of 78 paired NSCLC specimens and their adjacent normal tissues were collected in the study. Promoter methylation status was determined by methylation-specific polymerase chain reaction (MSP). DLEC1 gene expression was determined by RT-PCR and immunohistochemistry.
resultsAberrant methylation frequency of DLEC1, RASSF1A, hMLH1, RARβ and FHIT genes detected in 78 NSCLC tissues were 41.03%, 39.74%, 30.77% and 16.67%, respectively, which were all significantly higher than that in adjacent normal tissues. However, FHIT gene was not detected methylation in both cancerous and non-cancerous tissues. DLEC1 hypermethylation was associated with advanced stage (P=0.011) and lymph metastasis (P=0.019), while RASSF1A, RARβ, hMLH1 and mean methylation index (MI) were not correlated with any clinicopathological parameters. Moreover, DLEC1 gene downregulation was detected in 56.41% (44/78) NSCLC tissues and correlated with promoter hypermethylation.
conclusionsFrequent hypermethylation of TSGs located on chromosome 3p was a common event contributing to NSCLC pathogenesis and DLEC1 methylation was closely correlated with loss of expression.
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