SynthesisZhongguo fei ai za zhi = Chinese journal of lung cancer2011
[Meta analysis of association between Ser326Cys polymorphism of hOGG1 gene and risk of lung cancer].
Synthesis in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Smoking and hOGG1 Ser326Cys polymorphism contribute to lung cancer risk: evidence from a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Ethnic background and genetic variation in the evaluation of cancer risk: a systematic review.PloS one · 2014Pooled it
- hOGG1 Ser326Cys polymorphism and lung cancer susceptibility: a meta-analysis.Molecular biology reports · 2014Pooled it
- Association between the hOGG1 Ser326Cys polymorphism and lung cancer susceptibility: a meta-analysis based on 22,475 subjects.Diagnostic pathology · 2013Pooled it
- Association between the OGG1 Ser326Cys and APEX1 Asp148Glu polymorphisms and lung cancer risk: a meta-analysis.Molecular biology reports · 2012Pooled it
- DNA repair genes polymorphism and lung cancer risk with the emphasis to sex differences.Molecular biology reports · 2013Article
- The role of leptin receptor gene polymorphisms in determining the susceptibility and prognosis of NSCLC in Chinese patients.Journal of cancer research and clinical oncology · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveHuman 8-hydroxyguanine glycosylase (hOGG1) is one of the DNA repair genes, which can repair damaged DNA by specifically excising 8-dihydro-8-oxoguanine (8-OH-G). A considerable number of studies investigating hOGG1 Ser326Cys polymorphism were in relation to various cancers. However, the association of hOGG1 Ser326Cys polymorphism with risk of lung cancer is inconsistency. The aim of this study is to assess the association of hOGG1 Ser326Cys polymorphism with risk of lung cancer by conducting a meta-analysis.
methodsTo identify all studies that are qualified for meta-analysis, we conducted a computerized literature search of MEDLINE database (before November, 2010). Two investigators independently extracted the data and reached a consensus on all items.
resultsAccording to our search limits, twenty-two case-control studies, including 8,575 lung cancer cases and 9,484 controls, were selected for meta-analysis. Significant heterogeneity was found among those twenty-two case-control studies, when excluding two studies that were not accorded with Hard-Weinberg Equilibrium, the remains performed well homogeneity. Compared with Ser326 genotype, Cys326 genotype can significantly increase risk of lung cancer (OR=1.24, 95%CI: 1.10-1.39, P < 0.001), especially in Asian ethnic population and hospital population (OR=1.28, 95%CI: 1.11-1.49; OR=1.26, 95%CI: 1.09-1.46).
conclusionsThe present study indicates that the hOGG1 Ser326Cys polymorphism is associated with risk of lung cancer, Cys326 genotype can significantly increase risk of lung cancer.
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