Evidence map›Paper›PMID 21426626›Full record

SynthesisExpert reviews in molecular medicine2011

Electrophysiological markers of genetic risk for attention deficit hyperactivity disorder.

Charlotte Tye, Gráinne McLoughlin, Jonna Kuntsi, Philip Asherson

Abstract readSystematic Review
In one paragraph

Synthesis in Expert reviews in molecular medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Response time variability under slow and fast-incentive conditions in children with ASD, ADHD and ASD+ADHD.Journal of child psychology and psychiatry, and allied disciplines · 2016
    Article
  11. Review
  12. Article
  13. Article
  14. Shared genetic influences on ADHD symptoms and very low-frequency EEG activity: a twin study.Journal of child psychology and psychiatry, and allied disciplines · 2012
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Charlotte TyeMRC Social Genetic Developmental Psychiatry Centre (SGDP), Institute of Psychiatry, London, UK. charlotte.tye@kcl.ac.uk
Gráinne McLoughlin
Jonna Kuntsi
Philip Asherson

Funding

Medical Research Council G9817803
6 · The paper itself

Abstract

Attention deficit hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder with complex genetic aetiology. The identification of candidate intermediate phenotypes may facilitate the detection of susceptibility genes and neurobiological mechanisms underlying the disorder. Electroencephalography (EEG) is an ideal neuroscientific approach, providing a direct measurement of neural activity that demonstrates reliability, developmental stability and high heritability. This systematic review evaluates the utility of a subset of electrophysiological measures as potential intermediate phenotypes for ADHD: quantitative EEG indices of arousal and intraindividual variability, and functional investigations of attention, inhibition and performance monitoring using the event-related potential (ERP) technique. Each measure demonstrates consistent and meaningful associations with ADHD, a degree of genetic overlap with ADHD and potential links to specific genetic variants. Investigations of the genetic and environmental contributions to EEG/ERP and shared genetic overlap with ADHD might enhance molecular genetic studies and provide novel insights into aetiology. Such research will aid in the precise characterisation of the clinical deficits seen in ADHD and guide the development of novel intervention and prevention strategies for those at risk.

Indexed as

BiomarkersElectrophysiologyGenetic Predisposition to DiseaseAttention Deficit Disorder with HyperactivityElectroencephalographyGenetic TestingHumansBiomarkers

Identifiers

PMID21426626
PMCPMC4042910

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.