ArticleReproductive biology and endocrinology : RB&E2011
SERPINE2, an inhibitor of plasminogen activators, is highly expressed in the human endometrium during the secretory phase.
Article in Reproductive biology and endocrinology : RB&E, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 28 citations in OpenAlex.
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- Serpin peptidase inhibitor, clade E, member 2 in physiology and pathology: recent advancements.Frontiers in molecular biosciences · 2024Review
- DNA Methylation of Window of Implantation Genes in Cervical Secretions Predicts Ongoing Pregnancy in Infertility Treatment.International journal of molecular sciences · 2023Article
- Using Cumulus Cell Biopsy as a Non-Invasive Tool to Access the Quality of Bovine Oocytes: How Informative Are They?Animals : an open access journal from MDPI · 2022Article
- Analysis of the transcriptome of bovine endometrial cells isolated by laser micro-dissection (1): specific signatures of stromal, glandular and luminal epithelial cells.BMC genomics · 2021Article
- Serine Protease Inhibitor SERPINE2 Reversibly Modulates Murine Sperm Capacitation.International journal of molecular sciences · 2018Article
- Expression pattern of humanOncology letters · 2018Article
- Expression of cystatin C in the female reproductive tract and its effect on human sperm capacitation.Reproductive biology and endocrinology : RB&E · 2018Article
- Serum estradiol levels in controlled ovarian stimulation directly affect the endometrium.Journal of molecular endocrinology · 2017Article
- Clinical significance and evolution of hepatic HBsAg expression in HBeAg-positive patients receiving interferon therapy.Journal of gastroenterology · 2014Article
- Localization of a major susceptibility locus influencing preterm birth.Molecular human reproduction · 2013Article
- Article
- Spatiotemporal expression of SERPINE2 in the human placenta and its role in extravillous trophoblast migration and invasion.Reproductive biology and endocrinology : RB&E · 2011Article
- G Protein-coupled Estrogen Receptor 1 (GPER1) Regulates Expression ofCancer genomics & proteomicsArticle
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7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSERPINE2, also known as protease nexin-1, belongs to the serine protease inhibitor (SERPIN) superfamily. It is one of the potent SERPINs that modulates the activity of plasminogen activators (PAs). PAs and their SERPIN inhibitors, such as SERPINB2 and SERPINE1, were expressed in the human endometrium and were implicated in implantation. However, expression data about SERPINE2 in the human endometrium is still unknown. Thus, we conducted an investigation to reveal the spatiotemporal and cellular expression of SERPINE2 in the human uterus during the menstrual cycle.
methodsSeven patients who underwent a hysterectomy and samples of 120 archived patients' endometrial curettage or parts of the uterus that were formalin-fixed and embedded in paraffin. Western blotting was performed to evaluate the specificity and sensitivity of the antibody. Immunohistochemistry was conducted to localize the SERPINE2 expression site. Quantitative analysis was conducted to evaluate expression levels of SERPINE2 in various sub-phases of the menstrual cycle.
resultsThe SERPINE2 protein was primarily detected in the uterine fluid during the mid- and late-secretory phases of the menstrual cycle. It was predominantly expressed in the luminal and glandular epithelium, less in the myometrium, and only dispersedly in certain stromal cells throughout the menstrual cycle. A quantitative analysis of expression levels of SERPINE2 in the glandular epithelium revealed that it was highly expressed in the endometrium during the secretory phase compared to the proliferative phase.
conclusionsThe SERPINE2 protein is highly expressed in the endometrium during the secretory phase, indicating that it may participate in tissue remodeling involved in implantation.
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