Evidence map›Paper›PMID 21426178›Full record

ReviewFuture medicinal chemistry2010

Molecular imaging of in vivo gene expression.

Allison S Harney, Thomas J Meade

Abstract readReview
In one paragraph

Review in Future medicinal chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Analytical chemistry · 2020
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. MRI Reporter Genes for Noninvasive Molecular Imaging.Molecules (Basel, Switzerland) · 2016
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Allison S HarneyDepartment of Chemistry, Northwestern University, Evanston, IL 60208, USA.
Thomas J Meade

Funding

q-Modulated Magnetic Resonance Imaging Contrast AgentsR01EB005866 · NIBIB · NORTHWESTERN UNIVERSITY · PI MEADE, THOMAS J · 2005 to 2013
$2.2M
NIBIB NIH HHS R01 EB005866
6 · The paper itself

Abstract

Molecular imaging provides spatial and temporal information on cellular changes that occur during development and in disease. MRI and optical imaging of reporter genes allows for the visualization of promoter activity, protein-protein interactions, protein stability and the tracking of individual proteins and cells. Reporter genes can be genetically encoded in transgenic animals or detected through the administration of an exogenous contrast agent. Advances in molecular imaging of reporter genes have led to the development of imaging probes that detect changes in endogenous cellular changes. The ability to use contrast agents coupled with functional information on cellular events will allow for sensitive assessment of individual patient therapies, leading to an accurately tailored treatment regimen.

Indexed as

Gene ExpressionAnimalsContrast MediaFluorescent DyesGenes, ReporterLuminescenceMagnetic Resonance ImagingMolecular ImagingMolecular StructureContrast MediaFluorescent Dyes

Identifiers

PMID21426178
PMCPMC4507573

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.