Evidence map›Paper›PMID 21424870›Full record

ReviewWorld journal of surgery2011

Overview of the development of personalized genomic medicine and surgery.

F Charles Brunicardi, Richard A Gibbs, David A Wheeler, John Nemunaitis, William Fisher, John Goss, Changyi Chen

Abstract readReview
In one paragraph

Review in World journal of surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Metabolomics and Cell Therapy in Diabetes Mellitus.International journal of molecular and cellular medicine · 2019
    Review
  8. Review
  9. Molecular vision · 2017
    Article
  10. Review
  11. Genetic and molecular alterations in pancreatic cancer: implications for personalized medicine.Medical science monitor : international medical journal of experimental and clinical research · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

F Charles BrunicardiMichael E. DeBakey Department of Surgery, Baylor College of Medicine, 1709 Dryden Street, Suite 1500, Houston, TX 77030, USA. cbrunica@bcm.tmc.edu
Richard A Gibbs
David A Wheeler
John Nemunaitis
William Fisher
John Goss
Changyi Chen

Funding

The Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3M
PDX-1 is a Therapeutic Target for Pancreatic CancerR01CA095731 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRUNICARDI, FRANCIS CHARLES · 2002 to 2012
$2.6M
Intraislet Communication in Surgically-Altered PancreasR01DK046441 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI BRUNICARDI, FRANCIS CHARLES · 1998 to 2007
$1.9M
A Microbial Genome Reference Platform for MetagenomicsU54HG004973 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A, HIGHLANDER, SARAH KATHERINE · 2009 to 2010
$1.8M
NCI NIH HHS R01 CA095731NCI NIH HHS R01-CA095731NHGRI NIH HHS U54 HG003273NHGRI NIH HHS U54-HG003273NHGRI NIH HHS U54 HG004973NHGRI NIH HHS U54-HG004973NIDDK NIH HHS R01 DK046441NIDDK NIH HHS R01-DK46441
6 · The paper itself

Abstract

Personalized genomic medicine and surgery (PGMS) represents a new approach to health care that customizes patients' medical treatment according to their own genetic information. This new approach is the result of increased knowledge of the human genome and ways this information can be applied by physicians in the medical and surgical management of their patients. A patient's genotype can yield important information concerning disease susceptibility and the effectiveness of medications, therefore guiding specific, targeted imaging and treatment therapies. This review summarizes major achievements of human genomic studies and applications of genomics in health care. Five years ago we developed a model for the development of PGMS in which genomic profile guides choice of therapy. In this article we discussed our progress, including an updating of the model, and a future vision of PGMS.

Indexed as

Genetic TestingGenomicsHuman Genome ProjectHumansMolecular Targeted TherapyPharmacogeneticsPrecision MedicineRisk Factors

Identifiers

PMID21424870
PMCPMC3281749

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.