Evidence map›Paper›PMID 21424845›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2011

Left atrial reservoir function predicts atrial fibrillation recurrence after catheter ablation: a two-dimensional speckle strain study.

Mahek Mirza, Giuseppe Caracciolo, Uzma Khan, Naoyo Mori, Samir K Saha, Komandoor Srivathsan, Gregory Altemose, Luis Scott, Partho Sengupta, Arshad Jahangir

Registry-linked trialAbstract read
In one paragraph

Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02838914 (Assessment of Reconstruction and Inverse Reconstruction in Right Atrium by by Multimodal Echocardiographic Techniques for Atrial Fibrillation Patients Before and After Radiofrequency Ablation), which is not on this map. Cited by 46 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 3 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02838914 naunknown statusnot on this mapstarted 2015, after this paper: background citation

Assessment of Reconstruction and Inverse Reconstruction in Right Atrium by by Multimodal Echocardiographic Techniques for Atrial Fibrillation Patients Before and After Radiofrequency Ablation

TypeinterventionalSponsorXinhua Hospital, Shanghai Jiao Tong University School of MedicineRan2015 to 2019Enrolled80ConditionsParoxysmal Atrial FibrillationArmsradiofrequency ablation (RFCA)
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 106 citations in OpenAlex.

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  7. Global left atrial strain in the prediction of sinus rhythm maintenance after catheter ablation for atrial fibrillation.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2014
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mahek MirzaDivision of Cardiovascular Diseases, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA.
Giuseppe Caracciolo
Uzma Khan
Naoyo Mori
Samir K Saha
Komandoor Srivathsan
Gregory Altemose
Luis Scott
Partho Sengupta
Arshad Jahangir
Mayo Clinic in Arizona · US

Funding

Mitochondrial Dysfunction and Susceptibility to Atrial Fibrillation in the ElderlR01HL101240 · NHLBI · MAYO CLINIC ARIZONA · PI JAHANGIR, ARSHAD · 2010 to 2013
$2.3M
Human Senescence and CardioprotectionR01HL089542 · NHLBI · MAYO CLINIC ROCHESTER · PI JAHANGIR, ARSHAD · 2008 to 2011
$1.6M
NHLBI NIH HHS R01 HL089542NHLBI NIH HHS R01 HL089542-03NHLBI NIH HHS R01 HL101240
6 · The paper itself

Abstract

backgroundPredictors of atrial fibrillation (AF) recurrence after catheter ablation (CA) are not fully defined. We hypothesized that 2D left atrial (LA) regional strain maps would help identify abnormal atrial substrate that increases susceptibility to AF recurrence post-CA. METHODS AND

resultsSixty-three patients (63 ± 10 years, 60% male) underwent CA for symptomatic paroxysmal (75%) or persistent (25%) AF. Baseline LA mechanical function determined using speckle tracking echocardiography was compared between those with AF recurrence (AFR) and no recurrence post-CA. Bi-dimensional global and regional maps of LA wall velocity, strain, and strain rate (SR) were obtained during end ejection and early diastole. After 18 ± 12 months of follow-up, 34 patients were free of AFR post-CA. There were no differences in clinical characteristics, LA and LV volumes, and Doppler estimates of LV diastolic function and filling pressures at baseline between patients with recurrent AF and those that maintained sinus rhythm. However, the LA emptying fraction (55 ± 17% vs. 64 ± 14%, p = 0.04), global and regional systolic and diastolic strains, SR, and velocities were reduced in patients with recurrent AF. There was marked attenuation of peak LA lateral wall longitudinal strain (LS; 11 ± 7% vs. 20 ± 14%, p = 0.007) and SR (0.9 ± 0.4 vs.1.3 ± 0.6 s(-1), p = 0.01). Multivariate analysis revealed lateral wall LS (odds ratio = 1.15, 95% CI = 1.02-1.28, p = 0.01) as an independent predictor of AFR.

conclusionsRegional LA lateral wall LS is a pre-procedural determinant of AFR in patients undergoing CA, independent of LA enlargement. Characterization of atrial myocardial tissue properties by speckle tracking echo may aid the appropriate selection of adjunctive strategies and prognostication of patients undergoing CA.

Indexed as

Catheter AblationAgedAtrial FibrillationAtrial Function, LeftCase-Control StudiesChi-Square DistributionComorbidityEchocardiography, TransesophagealElectrocardiographyFemaleHeart AtriaHumansLinear ModelsMaleMiddle AgedPredictive Value of Tests

Identifiers

PMID21424845
PMCPMC3153595
OpenAlexW1969436800

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.