ArticleEcotoxicology (London, England)2011
The four cornerstones of Evolutionary Toxicology.
Article in Ecotoxicology (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.
- Evolutionary toxicology: Meta-analysis of evolutionary events in response to chemical stressors.Ecotoxicology (London, England) · 2016Pooled it
- Intraspecific diversity is critical to population-level risk assessments.Scientific reports · 2024Article
- Population-specific responses to pollution exposure suggest local adaptation of invasive red swamp crayfish Procambarus clarkii along the Mediterranean French coastline.Environmental science and pollution research international · 2024Article
- Freshwater salinization and the evolved tolerance of amphibians.Ecology and evolution · 2024Article
- Intraspecific genetic variation is critical to robust toxicological predictions of aquatic contaminants.bioRxiv : the preprint server for biology · 2023Article
- Population transcriptogenomics highlights impaired metabolism and small population sizes in tree frogs living in the Chernobyl Exclusion Zone.BMC biology · 2023Article
- Reduced genetic diversity of freshwater amphipods in rivers with increased levels of anthropogenic organic micropollutants.Evolutionary applications · 2022Article
- Unusual evolution of tree frog populations in the Chernobyl exclusion zone.Evolutionary applications · 2022Article
- Evidence of micro-evolution in Crocidura russula from two abandoned heavy metal mines: potential use of Cytb, CYP1A1, and p53 as gene biomarkers.Ecotoxicology (London, England) · 2021Article
- Association between Chromosome 4 and mercury accumulation in muscle of the three-spined stickleback (Evolutionary applications · 2021Article
- Review
- Survival on railway tracks of Geranium robertianum-a glyphosate-tolerant plant.Ecotoxicology (London, England) · 2021Article
- Testing for population differences in evolutionary responses to pesticide pollution in brown trout (Evolutionary applications · 2021Article
- Evolutionary Toxicology-An Informational Tool for Chemical Regulation?Environmental toxicology and chemistry · 2020Article
- Evolutionary Toxicogenomics of the Striped Killifish (International journal of molecular sciences · 2019Article
- Evolutionary concepts can benefit both fundamental research and applied research in toxicology (A comment on Brady et al. 2017).Evolutionary applications · 2019Article
- Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resistance in freshwater crustaceans.Evolutionary applications · 2018Article
- Evolutionary toxicology: Toward a unified understanding of life's response to toxic chemicals.Evolutionary applications · 2017Article
- Evolutionary toxicology in an omics world.Evolutionary applications · 2017Article
- Cost of Tolerance: Physiological Consequences of Evolved Resistance to Inhabit a Polluted Environment in Teleost Fish Fundulus heteroclitus.Environmental science & technology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evolutionary Toxicology is the study of the effects of chemical pollutants on the genetics of natural populations. Research in Evolutionary Toxicology uses experimental designs familiar to the ecotoxicologist with matched reference and contaminated sites and the selection of sentinel species. It uses the methods of molecular genetics and population genetics, and is based on the theories and concepts of evolutionary biology and conservation genetics. Although it is a relatively young field, interest is rapidly growing among ecotoxicologists and more and more field studies and even controlled laboratory experiments are appearing in the literature. A number of population genetic impacts have been observed in organisms exposed to pollutants which I refer to here as the four cornerstones of Evolutionary Toxicology. These include (1) genome-wide changes in genetic diversity, (2) changes in allelic or genotypic frequencies caused by contaminant-induced selection acting at survivorship loci, (3) changes in dispersal patterns or gene flow which alter the genetic relationships among populations, and (4) changes in allelic or genotypic frequencies caused by increased mutation rates. It is concluded that population genetic impacts of pollution exposure are emergent effects that are not necessarily predictable from the mode of toxicity of the pollutant. Thus, to attribute an effect to a particular contaminant requires a careful experimental design which includes selection of appropriate reference sites, detailed chemistry analyses of environmental samples and tissues, and the use of appropriate biomarkers to establish exposure and effect. This paper describes the field of Evolutionary Toxicology and discusses relevant field studies and their findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.