ArticlePflugers Archiv : European journal of physiology2011
cAMP target sequences enhCRE and CNRE sense low-salt intake to increase human renin gene expression in vivo.
Article in Pflugers Archiv : European journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- A Possible Link between Cell Plasticity and Renin Expression in the Collecting Duct: A Narrative Review.International journal of molecular sciences · 2024Review
- Renin cells with defective Gsα/cAMP signaling contribute to renal endothelial damage.Pflugers Archiv : European journal of physiology · 2019Article
- Article
- Persistent and inducible neogenesis repopulates progenitor renin lineage cells in the kidney.Kidney international · 2017Article
- Interference with GsJournal of the American Society of Nephrology : JASN · 2017Article
- PGEAmerican journal of physiology. Renal physiology · 2017Article
- The PPAR-gamma-binding sequence Pal3 is necessary for basal but dispensable for high-fat diet regulated human renin expression in the kidney.Pflugers Archiv : European journal of physiology · 2017Article
- Article
- Renin lineage cells repopulate the glomerular mesangium after injury.Journal of the American Society of Nephrology : JASN · 2015Article
- Classical Renin-Angiotensin system in kidney physiology.Comprehensive Physiology · 2014Review
- Control of renin [corrected] gene expression.Pflugers Archiv : European journal of physiology · 2013Review
- Chicken ovalbumin upstream promoter transcription factor II regulates renin gene expression.The Journal of biological chemistry · 2012Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to assess the role of cAMP target sequences enhancer cAMP response element (enhCRE) and cAMP and overlapping negative response element (CNRE) in the control of human renin gene (REN) in vivo. enhCRE and CNRE were silenced by mutations in a 12.2-kb human renin promoter fused to LacZ reporter gene. This construct was used to generate transgenic mice (RENMut-LacZ). The expression of the transgene was correctly targeted to the juxtaglomerular portions of renal afferent arterioles which express endogenous mouse renin. Therefore, enhCRE and CNRE do not seem to be relevant for the control of the cell-specific expression of the human renin gene. The β-adrenoreceptor agonist isoproterenol (10 mg/kg/day, for 2 days) stimulated the endogenous renin, but not the LacZ mRNA expression. Treatment of RENMut-LacZ mice with the angiotensin converting enzyme inhibitor (enalapril 10 mg/kg/day, for 7 days) or their crossing to angiotensin receptor type 1a knockout mice led to increased renin and LacZ mRNA levels. Renin expression was upregulated by low-salt diet (0.03% NaCl, for 10 days) and downregulated by high-salt diet (4% NaCl, for 10 days). In contrast, low-salt diet did not influence, while high-salt diet inhibited the expression of LacZ. In summary, enhCRE and CNRE appear to be necessary for the transactivation of the human renin gene through β-adrenoreceptors and by low-salt diet. Our data also suggest that different intracellular mechanisms mediate the effect of low- and high-salt intake on renin expression in vivo.
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