ArticlePediatric nephrology (Berlin, Germany)2011
Vesico-ureteric reflux: using mouse models to understand a common congenital urinary tract defect.
Article in Pediatric nephrology (Berlin, Germany), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Loss of peri-Wolffian duct stromal Frs2α expression in mice leads to abnormal ureteric bud induction and vesicoureteral reflux.Pediatric research · 2017Article
- Modulation of apoptotic response by LAR family phosphatases-cIAP1 signaling during urinary tract morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Estimation of the relationship between the polymorphisms of selected genes: ACE, AGTR1, TGFβ1 and GNB3 with the occurrence of primary vesicoureteral reflux.International urology and nephrology · 2017Article
- Urinary Tract Infection: Pathogenesis and Outlook.Trends in molecular medicine · 2016Review
- A Murine Model for Escherichia coli Urinary Tract Infection.Methods in molecular biology (Clifton, N.J.) · 2016Article
- α-Intercalated cells defend the urinary system from bacterial infection.The Journal of clinical investigation · 2014Article
- Vesicoureteric reflux and reflux nephropathy: from mouse models to childhood disease.Pediatric nephrology (Berlin, Germany) · 2014Review
- TNXB mutations can cause vesicoureteral reflux.Journal of the American Society of Nephrology : JASN · 2013Article
- 3-Dimensional morphometric analysis of murine bladder development and dysmorphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Vesico-ureteric reflux (VUR) is a common congenital urinary tract defect in which urine flows retrogradely from the bladder to the kidneys because of an abnormally formed uretero-vesical junction. It is associated with recurrent urinary tract infections, renal hypo/dysplasia, reflux nephropathy, hypertension, and end-stage renal disease. In humans, VUR is genetically and phenotypically heterogeneous, encompassing diverse renal and urinary tract phenotypes. To understand the significance of these phenotypes, we and others have used the mouse as a model organism and this has led to the identification of new candidate genes. Through careful phenotypic analysis of these models, a new understanding of the genetics and biology of VUR is now underway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.