ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2011
Dectin-1 and NOD2 mediate cathepsin activation in zymosan-induced arthritis in mice.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Pharmacological inhibition of receptor-interacting protein kinase 2 (RIPK2) elicits neuroprotective effects following experimental ischemic stroke.Experimental neurology · 2024Article
- Expression of Toll-like receptor 2, Dectin-1, and Osteopontin in murine model of pulpitis.Clinical oral investigations · 2023Article
- Nod2 Deficiency Augments Th17 Responses and Exacerbates Autoimmune Arthritis.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- The Expression of Dectin-1, Irak1 and Rip2 During the Host Response to Aspergillus fumigatus.Mycopathologia · 2018Article
- Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases.ACS medicinal chemistry letters · 2017Article
- Dectin-2 is a primary receptor for NLRP3 inflammasome activation in dendritic cell response to Histoplasma capsulatum.PLoS pathogens · 2017Article
- Blau syndrome-associated Nod2 mutation alters expression of full-length NOD2 and limits responses to muramyl dipeptide in knock-in mice.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- In vivo inhibition of RIPK2 kinase alleviates inflammatory disease.The Journal of biological chemistry · 2014Article
- Epicutaneous immunization with TNP-Ig and Zymosan induces TCRαβ+ CD4+ contrasuppressor cells that reverse skin-induced suppression via IL-17A.International archives of allergy and immunology · 2014Article
- TLR2 deletion promotes arthritis through reduction of IL-10.Journal of leukocyte biology · 2013Article
- Article
- Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases.Bioscience reports · 2012Review
- Impact of IL-1 signalling on experimental uveitis and arthritis.Annals of the rheumatic diseases · 2012Article
- C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses.Cellular & molecular immunology · 2012Review
- TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells.European journal of immunology · 2012Article
- NLRs in immune privileged sites.Current opinion in pharmacology · 2011Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveActivation of pattern recognition receptors (PRR) may contribute to arthritis. Here, we elucidated the role of NOD2, a genetic cause of inflammatory arthritis, and several other PRR in a murine model of inflammatory arthritis.
methodsThe roles of CR3, TLR2, MyD88, NOD1, NOD2, Dectin-1 and Dectin-2 were tested in vivo in arthritis elicited by intra-articular injections of zymosan, the fungal cell wall components curdlan, laminarin and mannan, and the bacterial cell wall peptidoglycan.
resultsDectin-1, and to a lesser extent Dectin-2, contributed to arthritis. TLR2, MyD88 and CR3 played non-essential roles. Observations based on injection of curdlan, laminarin or mannan supported the dominant role of the Dectin-1 pathway in the joint. We demonstrated differential roles for NOD1 and NOD2 and identified NOD2 as a novel and essential mediator of zymosan-induced arthritis.
conclusionsTogether, Dectin-1 and NOD2 are critical, sentinel receptors in the arthritogenic effects of zymosan. Our data identify a novel role for NOD2 during inflammatory responses within joints.
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