ArticleDiabetologia2011
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Article in Diabetologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 30 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Living With Statins - The Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being
Living With Statins - The Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being
LIFESTAT - Living With Statins, a Cross Sectional Study on the Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being
Who cites it
30 citing papers in PubMed, 70 citations in OpenAlex.
- Trial
- Four days of bed rest increases intrinsic mitochondrial respiratory capacity in young healthy males.Physiological reports · 2018Trial
- Supplemental Oxygen Improves In Vivo Mitochondrial Oxidative Phosphorylation Flux in Sedentary Obese Adults With Type 2 Diabetes.Diabetes · 2018Trial
- The effects of 2 weeks of statin treatment on mitochondrial respiratory capacity in middle-aged males: the LIFESTAT study.European journal of clinical pharmacology · 2017Trial
- Adalimumab Treatment Effects on Inflammation and Adipose Tissue Mitochondrial Respiration in Hidradenitis Suppurativa.Endocrinology, diabetes & metabolism · 2024Article
- Comprehensive interrogation of human skeletal muscle reveals a dissociation between insulin resistance and mitochondrial capacity.American journal of physiology. Endocrinology and metabolism · 2023Article
- Normalization of maternal adiponectin in obese pregnant mice prevents programming of impaired glucose metabolism in adult offspring.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Metabolic effects of alternate-day fasting in males with obesity with or without type 2 diabetes.Frontiers in physiology · 2022Article
- High metabolic substrate load induces mitochondrial dysfunction in rat skeletal muscle microvascular endothelial cells.Physiological reports · 2021Article
- Targeting Mitochondria in Diabetes.International journal of molecular sciences · 2021Review
- Type 2 diabetes-induced hyposalivation of the submandibular gland through PINK1/Parkin-mediated mitophagy.Journal of cellular physiology · 2020Article
- High-intensity interval training changes mitochondrial respiratory capacity differently in adipose tissue and skeletal muscle.Physiological reports · 2018Article
- Defects in skeletal muscle subsarcolemmal mitochondria in a non-obese model of type 2 diabetes mellitus.PloS one · 2017Article
- Mitochondrial Quality Control as a Therapeutic Target.Pharmacological reviews · 2016Review
- Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults.Experimental gerontology · 2015Article
- Reduced efficiency of sarcolipin-dependent respiration in myocytes from humans with severe obesity.Obesity (Silver Spring, Md.) · 2015Article
- Defining meal requirements for protein to optimize metabolic roles of amino acids.The American journal of clinical nutrition · 2015Article
- Article
- Heterozygous SOD2 deletion impairs glucose-stimulated insulin secretion, but not insulin action, in high-fat-fed mice.Diabetes · 2014Article
- Effects of exercise training on mitochondrial function in patients with type 2 diabetes.World journal of diabetes · 2014Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisMitochondrial respiration has been linked to insulin resistance. We studied mitochondrial respiratory capacity and substrate sensitivity in patients with type 2 diabetes (patients), and obese and lean control participants.
methodsMitochondrial respiration was measured in permeabilised muscle fibres by respirometry. Protocols for respirometry included titration of substrates for complex I (glutamate), complex II (succinate) and both (octanoyl-carnitine). Myosin heavy chain (MHC) composition, antioxidant capacity (manganese superoxide dismutase [MnSOD]), citrate synthase activity and maximal oxygen uptake (VO2) were also determined. Insulin sensitivity was determined with the isoglycaemic-hyperinsulinaemic clamp technique.
resultsInsulin sensitivity was different (p < 0.05) between the groups (patients<obese controls<lean controls). MnSOD was lower in patients than in lean controls. MHC I content was lowest in patients (37 ± 11% [mean ± SE] vs 53 ± 6% and 56 ± 4%) vs obese controls and lean controls, respectively. VO2 was highest in lean controls (40 ± 3 ml min(-1) kg(-1) [mean ± SE]) compared with patients (25 ± 2) and obese controls (27 ± 2). Mitochondrial content (citrate synthase) was higher (p < 0.05) in lean controls than in patients and obese controls. When normalised for mitochondrial content by citrate synthase, mitochondrial respiratory capacity was similar in all groups. However, the half maximal substrate concentration (C(50)) for complex I was significantly lower (p = 0.03) in patients (1.1 ± 0.2 mmol/l [mean ± SE]) than in obese (2.0 ± 0.3) and lean (1.8 ± 0.3) controls. Likewise, C(50) for complex II was lower (p = 0.02) in patients (3.5 ± 0.2 mmol/l [mean ± SE]) than in obese controls (4.1 ± 0.2), but did not differ from that in lean controls (3.8 ± 0.4). Substrate sensitivity for octanoyl-carnitine did not differ between groups. CONCLUSIONS/
interpretationIncreased mitochondrial substrate sensitivity is seen in skeletal muscle from type 2 diabetic patients and is confined to non-lipid substrates. Respiratory capacity per mitochondrion is not decreased with insulin resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.