ArticleInternational journal of colorectal disease2011
High survivin expression as a predictor of poor response to preoperative chemoradiotherapy in locally advanced rectal cancer.
Article in International journal of colorectal disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Predicting response to neoadjuvant chemoradiotherapy in rectal cancer: from biomarkers to tumor models.Therapeutic advances in medical oncology · 2022Review
- Next-Generation Sequencing May Discriminate Extreme Long-term versus Short-term Survival in Patients with Metastatic Small Cell Lung Cancer (SCLC).Translational oncology · 2019Article
- Article
- Immunohistochemical Markers as Predictors of Histopathologic Response and Prognosis in Rectal Cancer Treated with Preoperative Adjuvant Therapy: State of the Art.Gastroenterology research and practice · 2017Review
- Prognostic significance of survivin in rectal cancer patients treated with surgery and postoperative concurrent chemo-radiation therapy.Oncotarget · 2016Article
- Predictive value of vrk 1 and 2 for rectal adenocarcinoma response to neoadjuvant chemoradiation therapy: a retrospective observational cohort study.BMC cancer · 2016Article
- p27 expression in post-treatment rectal cancer: a potential novel approach for predicting residual nodal disease.American journal of surgery · 2014Article
- Over-expression of survivin and VEGF in small-cell lung cancer may predict the poorer prognosis.Medical oncology (Northwood, London, England) · 2014Article
- Monitoring survivin expression in cancer: implications for prognosis and therapy.Molecular diagnosis & therapy · 2013Review
- Overexpression of nuclear β-catenin in rectal adenocarcinoma is associated with radioresistance.World journal of gastroenterology · 2013Article
- Expression of survivin and its four splice variants in colorectal cancer and its clinical significances.Medical oncology (Northwood, London, England) · 2013Article
- hPEBP4 as a predictive marker for the pathological response of rectal cancer to preoperative radiotherapy.International journal of colorectal disease · 2013Article
- Significance of survivin expression: Prognostic value and survival in stage III non-small cell lung cancer.Experimental and therapeutic medicine · 2012Article
- Or why translational research is vital for the future treatment of rectal cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2011Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate seven molecular markers including cyclooxygenase -2, epidermal growth factor receptor, Ki-67, p21, survivin, thymidylate synthase, and vascular endothelial growth factor for prediction of response to preoperative chemoradiotherapy in locally advanced rectal cancer. MATERIALS AND
methodsFifty-four patients with clinical T3-4 and/or node-positive rectal cancer who underwent preoperative chemoradiotherapy followed by surgical resection were enrolled into this study. Preoperative chemoradiotherapy consisted of 50.4 Gy of pelvic irradiation with concomitant 5-fluorouracil or oral capecitabine. Expression of molecular markers in pretreatment paraffin-embedded tumor biopsy specimens was assessed by immunohistochemical staining on the tissue microarray. Tumor downstaging was used as an endpoint for evaluation of tumor response.
resultsTumor downstaging was observed in 22 patients (41%), and pathologic complete remission in 7 patients (13%). Among seven molecular markers, only survivin expression was significantly related with tumor downstaging: 26% with high survivin expression (>75% in extent) vs. 72% with low survivin expression (p = 0.0011). However, other six molecular markers were found not to have any correlation with tumor downstaging.
conclusionsHigh survivin expression in pretreatment tumor biopsy was associated with less tumor downstaging after preoperative chemoradiotherapy for locally advanced rectal cancer.
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