Trial reportBreast cancer research and treatment2011
Strength training stops bone loss and builds muscle in postmenopausal breast cancer survivors: a randomized, controlled trial.
Trial report in Breast cancer research and treatment, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 98 papers, 20 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Strength Training for Older Breast Cancer Survivors
Metabolic and Bone Changes After Adjuvant Cancer Treatments in Early Non-metastatic Breast Cancer - a 5-year Follow-up Study.
Who cites it
98 citing papers in PubMed, 20 syntheses or guidelines pooled it, 214 citations in OpenAlex.
- Do Combined Resistance and Aerobic Exercise Programs Cause an Interference Effect in Women with Breast Cancer? A Systematic Review and Network Meta-analysis.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Which Exercise Prescriptions Improve Physical Fitness in Patients with Breast Cancer Before, During, and Following Treatment? A Systematic Review and Meta-analysis of Randomized Controlled Trials.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Effect of exercise on bone-related outcomes in patients with cancer affected by bone metastases or bone loss: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Pooled it
- Effects of exercise interventions on bone health and body composition in postmenopausal women with breast cancer: a systematic review and meta-analysis.Frontiers in oncology · 2025Pooled it
- Resistance training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2024Pooled it
- Effects of Combined Interventions of Exercise and Diet or Exercise and Supplementation on Breast Cancer Patients: A Systematic Review.Nutrients · 2023Pooled it
- Impact of Physical Rehabilitation on Bone Biomarkers in Non-Metastatic Breast Cancer Women: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- Dose-response relationship of resistance training for muscle morphology and strength in elderly cancer patients: A meta-analysis.Frontiers in medicine · 2023Pooled it
- The effects of resistance training on muscular strength and hypertrophy in elderly cancer patients: A systematic review and meta-analysis.Journal of sport and health science · 2022Pooled it
- The effects of exercise on the bone health of people with cancer: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Pooled it
- The Effect of Resistance Training on Body Composition During and After Cancer Treatment: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Different Methods of Physical Training Applied to Women Breast Cancer Survivors: A Systematic Review.Frontiers in physiology · 2021Pooled it
- Optimising weight-loss interventions in cancer patients-A systematic review and network meta-analysis.PloS one · 2021Pooled it
- Body weight management in overweight and obese breast cancer survivors.The Cochrane database of systematic reviews · 2020Pooled it
- Association of Long-term Exercise Training With Risk of Falls, Fractures, Hospitalizations, and Mortality in Older Adults: A Systematic Review and Meta-analysis.JAMA internal medicine · 2019Pooled it
- Exercise for reducing falls in people living with and beyond cancer.The Cochrane database of systematic reviews · 2018Pooled it
- The effect of exercise on bone mineral density in adult cancer survivors: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Pooled it
- Physical activity for women with breast cancer after adjuvant therapy.The Cochrane database of systematic reviews · 2018Pooled it
- Exercise for improving bone health in women treated for stages I-III breast cancer: a systematic review and meta-analyses.Journal of cancer survivorship : research and practice · 2017Pooled it
- Non-pharmacological interventions for cognitive impairment due to systemic cancer treatment.The Cochrane database of systematic reviews · 2016Pooled it
38 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Targeted exercise training could reduce risk factors for fracture and obesity-related diseases that increase from breast cancer treatment, but has not been sufficiently tested. We hypothesized that progressive, moderate-intensity resistance + impact training would increase or maintain hip and spine bone mass, lean mass and fat mass and reduce bone turnover compared to controls who participated in a low-intensity, non-weight bearing stretching program. We conducted a randomized, controlled trial in 106 women with early stage breast cancer who were >1 year post-radiation and/or chemotherapy, ≥ 50 years of age at diagnosis and postmenopausal, free from osteoporosis and medications for bone loss, resistance and impact exercise naïve, and cleared to exercise by a physician. Women were randomly assigned to participate in 1 year of thrice-weekly progressive, moderate-intensity resistance + impact (jump) exercise or in a similar frequency and length control program of progressive, low-intensity stretching. Primary endpoints were bone mineral density (BMD; g/cm²) of the hip and spine and whole body bone-free lean and fat mass (kg) determined by DXA and biomarkers of bone turnover-serum osteocalcin (ng/ml) and urinary deoxypyrodiniline cross-links (nmol/mmolCr). Women in the resistance + impact training program preserved BMD at the lumbar spine (0.47 vs. -2.13%; P = 0.001) compared to controls. The resistance + impact group had a smaller increase in osteocalcin (7.0 vs. 27%, P = 0.03) and a larger decrease in deoxypyrodinoline (-49.9 vs. -32.6%, P = 0.06) than controls. Increases in lean mass from resistance + impact training were greatest among women currently taking aromatase inhibitors compared to controls not on this therapy (P = 0.01). Our combined program of resistance + impact exercise reduced risk factors for fracture among postmenopausal breast cancer survivors (BCS) and may be particularly relevant for BCS on aromatase inhibitors (AIs) because of the additional benefit of exercise on muscle mass that could reduce falls.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.