ArticlePsychopharmacology2011
Anxiolytic-like effects of somatostatin isoforms SST 14 and SST 28 in two animal models (Rattus norvegicus) after intra-amygdalar and intra-septal microinfusions.
Article in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Spatial Cell Atlas of Lateral Septum Reveals Changes Underlying Anxiety and Fear Learning Deficits in Mice with Abnormal Immunity.International journal of biological sciences · 2025Article
- Cholecystokinin-expressing interneurons mediated inhibitory transmission and plasticity in basolateral amygdala modulate stress-induced anxiety-like behaviors in mice.Neurobiology of stress · 2024Article
- Somatostatin: Linking Cognition and Alzheimer Disease to Therapeutic Targeting.Pharmacological reviews · 2024Review
- Behavioral Deficits Induced by Somatostatin-Positive GABA Neuron Silencing Are Rescued by Alpha 5 GABA-A Receptor Potentiation.The international journal of neuropsychopharmacology · 2021Article
- Prefrontal cortex interneurons display dynamic sex-specific stress-induced transcriptomes.Translational psychiatry · 2019Article
- Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments.Neuron · 2019Review
- Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions.Frontiers in cellular neuroscience · 2019Review
- Somatostatin-Positive Gamma-Aminobutyric Acid Interneuron Deficits in Depression: Cortical Microcircuit and Therapeutic Perspectives.Biological psychiatry · 2017Review
- Somatostatin depresses the excitability of subicular bursting cells: Roles of inward rectifier KHippocampus · 2017Article
- Roles of Hippocampal Somatostatin Receptor Subtypes in Stress Response and Emotionality.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Distribution of type I corticotropin-releasing factor (CRF1) receptors on GABAergic neurons within the basolateral amygdala.Synapse (New York, N.Y.) · 2017Article
- Decreased Numbers of Somatostatin-Expressing Neurons in the Amygdala of Subjects With Bipolar Disorder or Schizophrenia: Relationship to Circadian Rhythms.Biological psychiatry · 2017Article
- Characterization of GABAergic marker expression in the chronic unpredictable stress model of depression.Chronic stress (Thousand Oaks, Calif.) · 2017Article
- SSTR4, Childhood Adversity, Self-efficacy and Suicide Risk in Alcoholics.Translational neuroscience · 2017Article
- Somatostatin, neuronal vulnerability and behavioral emotionality.Molecular psychiatry · 2015Article
- Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?Frontiers in pharmacology · 2013Review
- Modulation of the adaptive response to stress by brain activation of selective somatostatin receptor subtypes.Peptides · 2013Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RATIONALE AND
objectivesSomatostatin (SST) isoforms, SST 14 and SST 28, inhibit regulatory hormones in the periphery (e.g., growth hormone) and are widely distributed in the brain. In recent experiments, intracerebroventricular (ICV) SST produced anxiolytic-like effects in both behavioral and electrophysiological models. The sites of action of these anxiolytic effects in the brain, however, and the relative contributions of SST 14 and SST 28 to these effects are unknown. MATERIALS AND
methodsAnxiolytic effects were assessed in the plus-maze and shock-probe tests after (1) intra-amygdalar microinfusion of SST 14 (0.5 or 3 μg per hemisphere) or SST 28 (3 μg per hemisphere), (2) intra-septal microinfusion of SST 14 (0.5 or 1.5 μg per hemisphere) or SST 28 (1.5 μg per hemisphere), or (3) intra-striatal microinfusion of SST 14 (3 μg per hemisphere).
resultsIntra-amygdalar and intra-septal microinfusions of SST 14 and SST 28 produced robust anxiolytic-like effects in the behavioral tests, unlike intra-striatal microinfusions. The magnitude of the anxiolytic effects in the amygdala and septum were comparable to those found previously with ICV SST 14, ICV L-779976, an SST (sst2) receptor agonist, and ICV diazepam, a classical benzodiazepine anxiolytic.
conclusionsSST receptors in the septum and amygdala are responsive to both SST 14 and SST 28, but not those in the striatum. Although no obvious differences in the anxiolytic-like effects of the isoforms were detected, quantitative or even qualitative differences in their specific anxiolytic effects may occur in different sub-regions of the septum and amygdala, as has been found for benzodiazepine anxiolytics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.