Trial reportSurgical endoscopy2011
Results of a phase I-II study on intraductal confocal microscopy (IDCM) in patients with common bile duct (CBD) stenosis.
Trial report in Surgical endoscopy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Diagnostic accuracy of probe-based confocal laser endomicroscopy and tissue sampling by endoscopic retrograde cholangiopancreatography in indeterminate biliary strictures: a meta‑analysis.Scientific reports · 2022Pooled it
- Confocal Laser Endomicroscopy in Gastrointestinal and Pancreatobiliary Diseases: A Systematic Review and Meta-Analysis.BioMed research international · 2016Pooled it
- Probe based confocal laser endomicroscopy of the pancreatobiliary system.World journal of gastroenterology · 2015Pooled it
- Confocal laser endomicroscopy improves diagnosis of cholangiocarcinoma: a case report and review.Open life sciences · 2026Article
- Current controversies and advances in the management of pancreatic adenocarcinoma.World journal of gastrointestinal oncology · 2021Review
- SAGES TAVAC safety and efficacy analysis confocal laser endomicroscopy.Surgical endoscopy · 2021Review
- Diagnosis of Biliary Strictures Using Probe-Based Confocal Laser Endomicroscopy under the Direct View of Peroral Cholangioscopy: Results of a Prospective Study (with Video).Gastroenterology research and practice · 2020Article
- Identification of liver metastases with probe-based confocal laser endomicroscopy at two excitation wavelengths.Lasers in surgery and medicine · 2017Article
- Imaging in pancreatic disease.Nature reviews. Gastroenterology & hepatology · 2017Review
- Novel biomarkers and endoscopic techniques for diagnosing pancreaticobiliary malignancy.F1000Research · 2017Review
- Imaging hamster model of bile duct cancer in vivo using fluorescent L-glucose derivatives.Human cell · 2016Article
- Utilizing confocal laser endomicroscopy for evaluating the adequacy of laparoscopic liver ablation.Lasers in surgery and medicine · 2016Article
- Role of endoscopic retrograde cholangiopancreatography in the management of benign biliary strictures: What's new?World journal of gastrointestinal endoscopy · 2016Review
- Advanced endoscopic imaging of indeterminate biliary strictures.World journal of gastrointestinal endoscopy · 2015Review
- Evaluation of pCLE in the bile duct: final results of EMID study : pCLE: impact in the management of bile duct strictures.Surgical endoscopy · 2015Article
- Use of probe-based confocal laser endomicroscopy (pCLE) in gastrointestinal applications. A consensus report based on clinical evidence.United European gastroenterology journal · 2015Review
- Diagnosis and management of primary sclerosing cholangitis-perspectives from a therapeutic endoscopist.World journal of hepatology · 2015Review
- Laparoscopic manipulation of a probe-based confocal laser endomicroscope using a steerable intravascular catheter.Surgical laparoscopy, endoscopy & percutaneous techniques · 2015Article
- Probe-based confocal laser endomicroscopy for indeterminate biliary strictures: refinement of the image interpretation classification.Gastroenterology research and practice · 2015Article
- Novel endoscopic approaches in the diagnosis and management of biliary strictures.F1000prime reports · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConfocal endomicroscopy is an emergent technique and allows real optical biopsies in the gastrointestinal (GI) tract. The aim of this study was to evaluate a new intraductal confocal miniprobe in patients with a normal common bile duct (CBD) or with a suspicion of a malignant stenosis (cholangiocarcinoma).
methodsThirty-seven patients (23 males) underwent endoscopic retrograde cholangiopancreatography (ERCP) for bile duct stone removal (7 cases) or bile duct stenosis (30 cases). Intraductal confocal microscopy (IDCM) was performed during the ERCP using a probe-based confocal laser endomicroscopy (pCLE) technique. IDCM was done with the CholangioFlex probe with Cellvizio (Mauna Kea Technologies, Paris, France). The depth of penetration of theCholangioFlex probe was 40-70 μm and magnification was 400×. Images were reviewed by an experienced pathologist in GI disease and compared to ERCP findings, CBD biopsies performed during ERCP or EUS, and in 15 patients to the resected specimen (Wipple resection).
resultsNo complications related to the CholangioFlex insertion occurred after the ERCP. Good images were obtained in 33 patients. Final histology diagnosis was a normal CBD in 7 cases, 23 malignant stenoses (4 ampullary carcinomas, 13 cholangiocarcinomas, and 6 pancreatic cancer), and 7 inflammatory stenoses (4 chronic pancreatitis, 1 stenosis of hepaticojejunal anastomosis, 1 postcholecystectomy CBD stenosis, and 1 primary sclerosing cholangitis). IDCM of a normal CBD showed a thin black band (<20 μm), normal vessels (thin and regular), and no visible glands. IDCM of malignant strictures revealed irregular vessels with lack of contrast in the CBD wall, large black band (>20 μm), and an aggregate of irregular black cells (black clumps). These aspects were seen in all malignant stenoses and none were seen in benign or normal CBD. The presence of irregular vessels, large black bands, and black clumps seen with confocal laser microscopy enabled prediction of neoplasia with an accuracy rate of 86%, sensitivity of 83%, and specificity of 75%. The respective numbers for standard histopathology were 53, 65, and 53%.
conclusionThis phase I-II study on IDCM showed that IDCM is feasible. This new technique will open a new door for optical biopsy of the CBD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.