ReviewPharmaceutical research2011
Self-assembled and nanostructured siRNA delivery systems.
Review in Pharmaceutical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
- Encapsulation of miRNA and siRNA into Nanomaterials for Cancer Therapeutics.Pharmaceutics · 2022Review
- Applications and perspectives of polyphenol-loaded solid lipid nanoparticles and nanostructured lipid carriers for foods.Food science and biotechnology · 2022Review
- Albumin Nanostructures for Nucleic Acid Delivery in Cancer: Current Trend, Emerging Issues, and Possible Solutions.Cancers · 2021Review
- Silencing the roadblocks to effective triple-negative breast cancer treatments by siRNA nanoparticles.Endocrine-related cancer · 2017Review
- Nanoengineered strategies for siRNA delivery: from target assessment to cancer therapeutic efficacy.Drug delivery and translational research · 2017Review
- Bulk and nanoscale polypeptide based polyelectrolyte complexes.Advances in colloid and interface science · 2017Review
- Chitosan-Based Nano-Embedded Microparticles: Impact of Nanogel Composition on Physicochemical Properties.Pharmaceutics · 2016Article
- Hyaluronic Acid-Based Nanogels Produced by Microfluidics-Facilitated Self-Assembly Improves the Safety Profile of the Cationic Host Defense Peptide Novicidin.Pharmaceutical research · 2015Article
- Extracellular vesicles and their synthetic analogues in aging and age-associated brain diseases.Biogerontology · 2015Review
- Design and in vitro evaluation of layer by layer siRNA nanovectors targeting breast tumor initiating cells.PloS one · 2014Article
- Investigations on agglomeration and haemocompatibility of vitamin E TPGS surface modified berberine chloride nanoparticles.BioMed research international · 2014Article
- Targeted delivery of antisense oligonucleotides by chemically self-assembled nanostructures.Molecular pharmaceutics · 2013Article
- Imaging mRNA expression levels in living cells with PNA·DNA binary FRET probes delivered by cationic shell-crosslinked nanoparticles.Organic & biomolecular chemistry · 2013Article
- Nuclease-resistant DNA via high-density packing in polymeric micellar nanoparticle coronas.ACS nano · 2013Article
- Dendrimers for siRNA Delivery.Pharmaceuticals (Basel, Switzerland) · 2013Article
- Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and Challenges.Pharmaceuticals (Basel, Switzerland) · 2013Article
- Molecular targeting of liposomal nanoparticles to tumor microenvironment.International journal of nanomedicine · 2013Review
- Solid formulation of cell-penetrating peptide nanocomplexes with siRNA and their stability in simulated gastric conditions.Journal of controlled release : official journal of the Controlled Release Society · 2012Article
- Bioreducible crosslinked polyelectrolyte complexes for MMP-2 siRNA delivery into human vascular smooth muscle cells.Pharmaceutical research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A wide range of organic and inorganic materials have been used in the development of nano-scale self-assembling gene delivery systems to improve the therapeutic efficacy of nucleic acid drugs. Small interfering RNA (siRNA) has recently been recognized as a promising and potent nucleic acid medicine for the treatment of incurable genetic disorders including cancer; however, siRNA-based therapeutics suffer from the same delivery problems as conventional nucleic acid drugs such as plasmid DNA and antisense oligonucleotides. Many of the delivery strategies developed for nucleic acid drugs have been applied to siRNA therapeutics, but they have not produced satisfactory in vivo gene silencing efficiencies to warrant clinical trials. This review discusses recent progress in the development of self-assembled and nanostructured delivery systems for efficient siRNA-induced gene silencing and their potential application in clinical settings.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.