Trial reportPloS one2011
Cowhage-induced itch as an experimental model for pruritus. A comparative study with histamine-induced itch.
Trial report in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Itch Relieving Effect of Botox: a Study in Healthy Subjects
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine
Who cites it
39 citing papers in PubMed, 96 citations in OpenAlex.
- Trial
- Prolonged Antipruritic Effect of Botulinum Toxin Type A on Cowhage-induced Itch: A Randomized, Single-blind, Placebo-controlled Trial.Acta dermato-venereologica · 2023Trial
- Antipruritic Effect of Topical Acetaminophen Gel in Histaminergic and Non-histaminergic Itch Provocation: A Double-blind, Vehicle-controlled Pilot Study.Acta dermato-venereologica · 2022Trial
- Nocebo Effects on Cowhage-evoked Itch: A Randomized Controlled Trial of Classical Conditioning and Observational Learning.Acta dermato-venereologica · 2021Trial
- Minimizing nocebo effects by conditioning with verbal suggestion: A randomized clinical trial in healthy humans.PloS one · 2017Trial
- Trial
- Machine Learning-Derived Neural Signatures of Itch and Pain That Reliably Distinguish the Two Sensations in Humans: A Proof-Of-Concept Study.European journal of pain (London, England) · 2026Article
- Experimental acute muscle pain and itch induce similar inhibitory effects on corticospinal excitability.Pain reports · 2025Article
- The neuroscience of itch in relation to transdiagnostic psychological approaches.Scientific reports · 2024Article
- Exploring oak processionary caterpillar induced lepidopterism (Part 1): unveiling molecular insights through transcriptomics and proteomics.Cellular and molecular life sciences : CMLS · 2024Article
- Exploring oak processionary caterpillar induced lepidopterism (part 2): ex vivo bio-assays unmask the role of TRPV1.Cellular and molecular life sciences : CMLS · 2024Article
- How Does Botulinum Toxin Inhibit Itch?Toxins · 2022Review
- Induction and generalization of nocebo effects on itch.Experimental dermatology · 2022Article
- Mild Skin Heating Evokes Warmth Hyperknesis Selectively for Histaminergic and Serotoninergic Itch in Humans.Acta dermato-venereologica · 2022Article
- Effects of Salicornia-Based Skin Cream Application on Healthy Humans' Experimental Model of Pain and Itching.Pharmaceuticals (Basel, Switzerland) · 2022Article
- The Spino-Parabrachial Pathway for Itch.Frontiers in neural circuits · 2022Review
- Review
- Characterization of Cowhage-induced Pruritus in Sensitive Skin: An Observational Laboratory Study.Acta dermato-venereologica · 2021Observational
- Transcutaneous Slowly Depolarizing Currents Elicit Pruritus in Patients with Atopic Dermatitis.Acta dermato-venereologica · 2020Article
- Flare Size but Not Intensity Reflects Histamine-Induced Itch.Skin pharmacology and physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHistamine is the prototypical pruritogen used in experimental itch induction. However, in most chronic pruritic diseases, itch is not predominantly mediated by histamine. Cowhage-induced itch, on the other hand, seems more characteristic of itch occurring in chronic pruritic diseases.
objectivesWe tested the validity of cowhage as an itch-inducing agent by contrasting it with the classical itch inducer, histamine, in healthy subjects and atopic dermatitis (AD) patients. We also investigated whether there was a cumulative effect when both agents were combined.
methodsFifteen healthy individuals and fifteen AD patients were recruited. Experimental itch induction was performed in eczema-free areas on the volar aspects of the forearm, using different itch inducers: histamine, cowhage and their combination thereof. Itch intensity was assessed continuously for 5.5 minutes after stimulus application using a computer-assisted visual analogue scale (COVAS).
resultsIn both healthy and AD subjects, the mean and peak intensity of itch were higher after the application of cowhage compared to histamine, and were higher after the combined application of cowhage and histamine, compared to histamine alone (p<0.0001 in all cases). Itch intensity ratings were not significantly different between healthy and AD subjects for the same itch inducer used; however AD subjects exhibited a prolonged itch response in comparison to healthy subjects (p<0.001).
conclusionsCowhage induced a more intense itch sensation compared to histamine. Cowhage was the dominant factor in itch perception when both pathways were stimulated in the same time. Cowhage-induced itch is a suitable model for the study of itch in AD and other chronic pruritic diseases, and it can serve as a new model for testing antipruritic drugs in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.