ArticlePLoS genetics2011
A cholinergic-regulated circuit coordinates the maintenance and bi-stable states of a sensory-motor behavior during Caenorhabditis elegans male copulation.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Inferences of glia-mediated control in Caenorhabditis elegans.Journal of neuroscience research · 2021Article
- Article
- The MakorineLife · 2019Article
- Sexual Dimorphism and Sex Differences inGenetics · 2018Article
- Article
- Article
- Short-term nicotine exposure induces long-lasting modulation of gustatory plasticity inBiochemistry and biophysics reports · 2016Article
- Neural circuits for sexually dimorphic and sexually divergent behaviors in Caenorhabditis elegans.Current opinion in neurobiology · 2016Review
- Expression of nicotinic acetylcholine receptor subunits from parasitic nematodes in Caenorhabditis elegans.Molecular and biochemical parasitology · 2015Article
- DOP-2 D2-Like Receptor Regulates UNC-7 Innexins to Attenuate Recurrent Sensory Motor Neurons during C. elegans Copulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Spillover transmission is mediated by the excitatory GABA receptor LGC-35 in C. elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- Article
- Dramatic fertility decline in aging C. elegans males is associated with mating execution deficits rather than diminished sperm quality.Experimental gerontology · 2013Article
- The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery.Genome biology · 2013Article
- Review
- The C. elegans male exercises directional control during mating through cholinergic regulation of sex-shared command interneurons.PloS one · 2013Article
- Article
- Oxytocin/vasopressin-related peptides have an ancient role in reproductive behavior.Science (New York, N.Y.) · 2012Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Penetration of a male copulatory organ into a suitable mate is a conserved and necessary behavioral step for most terrestrial matings; however, the detailed molecular and cellular mechanisms for this distinct social interaction have not been elucidated in any animal. During mating, the Caenorhabditis elegans male cloaca is maintained over the hermaphrodite's vulva as he attempts to insert his copulatory spicules. Rhythmic spicule thrusts cease when insertion is sensed. Circuit components consisting of sensory/motor neurons and sex muscles for these steps have been previously identified, but it was unclear how their outputs are integrated to generate a coordinated behavior pattern. Here, we show that cholinergic signaling between the cloacal sensory/motor neurons and the posterior sex muscles sustains genital contact between the sexes. Simultaneously, via gap junctions, signaling from these muscles is transmitted to the spicule muscles, thus coupling repeated spicule thrusts with vulval contact. To transit from rhythmic to sustained muscle contraction during penetration, the SPC sensory-motor neurons integrate the signal of spicule's position in the vulva with inputs from the hook and cloacal sensilla. The UNC-103 K(+) channel maintains a high excitability threshold in the circuit, so that sustained spicule muscle contraction is not stimulated by fewer inputs. We demonstrate that coordination of sensory inputs and motor outputs used to initiate, maintain, self-monitor, and complete an innate behavior is accomplished via the coupling of a few circuit components.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.