Trial reportPloS one2011
Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures.
Trial report in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 64 citations in OpenAlex.
- Consequences of a human TRPA1 genetic variant on the perception of nociceptive and olfactory stimuli.PloS one · 2014Trial
- Trial
- Trial
- Resolving Interpretation Challenges in Machine Learning Feature Selection With an Iterative Approach in Biomedical Pain Data.European journal of pain (London, England) · 2026Article
- Article
- A model-agnostic framework for dataset-specific selection of missing value imputation methods in pain-related numerical data.Canadian journal of pain = Revue canadienne de la douleur · 2026Article
- Biochemical Effects of Long-Term Exercise on Oxidative Stress and Antioxidant Markers in Adolescent Female Athletes.Children (Basel, Switzerland) · 2025Article
- Ganoderma tsuage promotes pain sensitivity in aging mice.Scientific reports · 2024Article
- Machine learning analysis predicts a person's sex based on mechanical but not thermal pain thresholds.Scientific reports · 2023Article
- Recursive computed ABC (cABC) analysis as a precise method for reducing machine learning based feature sets to their minimum informative size.Scientific reports · 2023Article
- Identification of sex-specific genetic associations in response to opioid analgesics in a White, non-Hispanic cohort from Southeast Minnesota.The pharmacogenomics journal · 2022Article
- Computational Functional Genomics-Based AmpliSeq™ Panel for Next-Generation Sequencing of Key Genes of Pain.International journal of molecular sciences · 2021Article
- Machine-Learned Association of Next-Generation Sequencing-Derived Variants in Thermosensitive Ion Channels Genes with Human Thermal Pain Sensitivity Phenotypes.International journal of molecular sciences · 2020Article
- A non-parametric effect-size measure capturing changes in central tendency and data distribution shape.PloS one · 2020Article
- Article
- Identifying the pathways required for coping behaviours associated with sustained pain.Nature · 2019Article
- Risk Factors and Prevention Strategies for Postoperative Opioid Abuse.Pain research & management · 2019Review
- Traits associated with central pain augmentation in the Knee Pain In the Community (KPIC) cohort.Pain · 2018Article
- Development of an AmpliSeqFrontiers in pharmacology · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVarious effects on pain have been reported with respect to their statistical significance, but a standardized measure of effect size has been rarely added. Such a measure would ease comparison of the magnitude of the effects across studies, for example the effect of gender on heat pain with the effect of a genetic variant on pressure pain. METHODOLOGY/PRINCIPAL
findingsEffect sizes on pain thresholds to stimuli consisting of heat, cold, blunt pressure, punctuate pressure and electrical current, administered to 125 subjects, were analyzed for 29 common variants in eight human genes reportedly modulating pain, gender and sensitization procedures using capsaicin or menthol. The genotype explained 0-5.9% of the total interindividual variance in pain thresholds to various stimuli and produced mainly small effects (Cohen's d 0-1.8). The largest effect had the TRPA1 rs13255063T/rs11988795G haplotype explaining >5% of the variance in electrical pain thresholds and conferring lower pain sensitivity to homozygous carriers. Gender produced larger effect sizes than most variant alleles (1-14.8% explained variance, Cohen's d 0.2-0.8), with higher pain sensitivity in women than in men. Sensitization by capsaicin or menthol explained up to 63% of the total variance (4.7-62.8%) and produced largest effects according to Cohen's d (0.4-2.6), especially heat sensitization by capsaicin (Cohen's d = 2.6).
conclusionsSensitization, gender and genetic variants produce effects on pain in the mentioned order of effect sizes. The present report may provide a basis for comparative discussions of factors influencing pain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.